Naslov
MECHANICAL PROPERTIES OF MEDICAL-GRADE POLY(LACTIC ACID)-BASED SCAFFOLD DURING IN VITRO DEGRADATION

Autori
Bauer, Leonard ; Rogina, Anamarija ; Zajec, Marko ; Drvar, Nenad ; Ivanković, Marica ; Ivanković, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Conference MATRIB 2023 - Materials, Tribology, Recycling Book of abstracts / Džijan, Ivo ; Šolić, Sanja ; Tropša, Vlado - Zagreb : Hrvatsko društvo za materijale i tribologiju (HDMT), 2023, 17-18

Skup
International Conference MATRIB 2023 - Materials, Tribology & Recycling

Mjesto i datum
Vela Luka, Hrvatska, 29.06.2023. - 01.07.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
poly(lactic-acid), chitosan, hydroxyapatite, additive manufacturing, scaffold

Sažetak
Tissue engineering and regenerative medicine represent an alternative approach for bone defect treatment by using biodegradable and biocompatible scaffolds as temporary supports for cell adhesion, proliferation and tissue regeneration. More importantly, such scaffolds should degrade at controlled rate in vivo leaving space for neotissue growth. Poly(lactic acid), PLA, is one of the most used biodegradable polymers for additive manufacturing of bone scaffolds due to its low melting temperature for melt extrusion. However, biomaterials with a strictly defined composition and high purity are required in clinical practices. The compositional difference between technical-grade and medical-grade biodegradable polymers leads to different material behaviour in vitro and in vivo. In this work, we investigated the mechanical behaviour of 3D-printed medical-grade PLA-based scaffolds during in vitro degradation. The initial 3D-printed PLA scaffolds were modified by chitosan-hydroxyapatite hydrogel to enhance the bioactivity of potential bone scaffold. Modified PLA scaffolds were incubated in enzymatic medium and simulated body fluid (Hanks’ balanced salt solution) for 8 weeks at 37°C to test compressive strength of scaffolds under in vitro conditions. The compression tests showed no significant difference in Young’s modulus and compressive strength indicating that modified PLA scaffolds maintained mechanical stability during prolonged incubation period. Furthermore, there was no significant difference in mechanical properties of the scaffolds incubated in different buffer solutions.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Strojarstvo, Temeljne tehničke znanosti

POVEZANOST RADA