Naslov
Viral pathogens associated with acute respiratory illness in hospitalized adults and elderly from Zagreb, Croatia, 2016 to 2018

Autori
Civljak, Rok ; Tot, Tatjana ; Falsey, Ann R. ; Huljev, Eva ; Vranes, Jasmina ; Ljubin‐Sternak, Suncanica

Izvornik
Journal of Medical Virology (0146-6615) 91 (2019), 7; 1202-1209

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human metapneumovirus ; influenza ; multiplex reverse-transtription polymerase chain reaction ; respiratory syncytial virus

Sažetak
Aims: To investigate the viral aetiology of acute respiratory infection (ARI) in hospitalized adults and elderly patients in Croatia, compare the prevalence of detected viruses, and to determine clinical characteristics and seasonal occurrence of investigated infections. Methods: From January 2016 to June 2018, a total of 182 adult patients presented with symptoms of ARI and admitted to the hospital were tested for 15 respiratory viruses by multiplex RT-PCR. Clinical data were collected by retrospective analysis of the patient’s chart. Results: A virus was identified in 106 (58.5%) of the patients. The most commonly detected virus was influenza virus (41.5%), followed by respiratory syncytial virus (13.8%), human metapneumovirus (13.0%), parainfluenza viruses (12.2%), rhinoviruses (11.4%), adenovirus and coronaviruses with equal frequencies (3.3%), and enterovirus (1.6%). The serum level of C-reactive protein and white blood cell count were significantly lower in patients with respiratory viruses identified when compared to those in whom no virus was detected (P>0.001 and P=0.007 respectively). There were no differences in clinical symptoms according to the type of the detected virus, except for more frequent illness exposure recall for influenza infection (P=0.010). Influenza, parainfluenza and pneumoviruses were detected mostly in winter months, while rhinoviruses in autumn and spring. Conclusions: In addition to influenza, pneumoviruses, rhinoviruses and parainfluenza viruses play an important role in aetiology of ARIs in adults. Fast and accurate laboratory diagnosis for respiratory viruses in routine practice is needed for clinicians optimally manage patients with ARI and potentially avoid the unnecessary use of antimicrobial drugs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA