Naslov
Influence of hydroxyapatite content on physical and rheological properties of chitosan-based scaffold

Autori
Dornjak, Luka ; Faraguna, Fabio ; Rogina, Anamarija

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
MATRIB 2023 - 23rd International conference on Materials, Tribology & Recycling / - , 2023, 39-39 / - , 2023, 39-39

Skup
MATRIB 2023 - 23rd International conference on Materials, Tribology & Recycling

Mjesto i datum
Vela Luka, Hrvatska, 29.06.2023. - 01.07.2023

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chitosan, hydroxyapatite, scaffold, rheological properties

Sažetak
Chitosan-based scaffolds offer significant potential in tissue engineering and regenerative medicine. Whilst exhibiting great bio-regenerative and biocompatible properties, their mechanical properties remain quite low. The presented research is focused on the modification of microporous chitosan scaffolds with various amounts of bioactive ceramics (hydroxyapatite) and its influence on physical and rheological properties of the composite scaffold. Chitosan/hydroxyapatite composite scaffolds with a highly porous microstructure have been prepared by suspending hydroxyapatite (HAp) particles into the chitosan matrix. According to SEM imaging, homogeneous dispersion of inorganic phase in chemically-crosslinked chitosan matrix had been achieved. The obtained composite scaffolds exhibited lower swelling capacity with respect to pure chitosan after 24 h of incubation in Hanks’ balanced salt solution. Rheological measurements show an increase in storage and loss modulus indicating an improvement in mechanical properties under shear stress. Furthermore, no significant change in loss factor (tanδ) was observed indicating no change in composite viscoelastic properties with an increase in HAp content.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Temeljne tehničke znanosti

POVEZANOST RADA