Naslov
Correlation between inflammatory parameters and bloodstream infections caused by multidrug resistant Gram- negative bacteria in critically ill COVID-19 patients – retrospective single-center study

Autori
Sakan, Sanja ; Kralik, Kristina ; Mihelčić, Antonija ; Hleb, Sonja ; Blagaj, Vanja ; Čučković, Marcela ; Dobrović, Karolina ; Mikecin, Verica ; Kristović, Darko ; Desnica, Marina ; Sojčić, Nataša ; Bradić, Nikola ; Šribar, Andrej ; Šafarić Oremuš, Zrinka ; Peršec, Jasminka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Liječnički vjesnik-Suplement / Peršec, Jasminka - Zagreb : Hrvatski liječnički zbor, 2022, 31-36

Skup
Simpozij intenzivne medicine-30 godina Hrvatskog društva za intenzivnu medicinu

Mjesto i datum
Zadar, Hrvatska, 20.05.2022. - 22.05.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Recenziran

Ključne riječi
COVID-19 PANDEMICS ; GRAM-NEGATIVE BACTERIA ; ACINETOBACTER BAUMANNII ; KLEBSIELLA

Sažetak
. Objectives: During the COVID-19 pandemics we have seen in critically ill COVID-19 patients treated in the intensive care unit the parallel outbreak of multidrug resistant Gram-negative bacteria bloodstream infections, mainly Acinetobacter baumannii and Klebsiella pneumoniae. Methods: We conducted a retrospective cohort single-center study. The aim was to investigate the incidence, etiology and impact of intensive care unit bloodstream infections in COVID-19 patients admitted to the COVID-19 intensive care unit with a known burden of multidrug resistance and to evaluate the possibility that inflammatory parameters levels measured at two different time points of treatment can early predict multidrug resistant Gram-negative bacteria bloodstream infections and enable timely beginning of bacterial targeted antimicrobial therapy. Results: Our study confirmed that procalcitonin values of 2, 46 mcg/L and neutrophil/lymphocyte ratio of 28, 9 could be a reliable indicators for high risk stratification of multidrug resistant Gram- negative bacterial infection origin in critically ill COVID-19 patients (Mann Whitney U test, P=0, 02). Conclusion: Monitoring dynamic shift of inflammatory parameters in critically ill COVID-19 patients could reliably help clinician to recognize the multidrug resistant Gram-negative bacteria bloodstream infections and start with the antimicrobial therapy in a timely manner

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA