Naslov
Clinical and demographic features with outcome predictors of adult patients with acute intoxication admitted to a medical intensive care unit in the Mediterranean part of Croatia

Autori
Kovacic, Vedran ; Kvartuc, Lukas ; Mikacic, Marijana ; Jerkovic, Ivan ; Begovic, Tanja Ilic ; Maras, Marina ; Nazlic, Jurica

Izvornik
Toxicology Research (2045-4538) Tfad054 (2023); 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
intoxication ; acutecare ; intensivecare ; toxicology ; epidemiology.

Sažetak
Background The objective of the study was to assess the demographics, clinical parameters, and outcome of acute intoxications among adult patients admitted to a medical intensive care unit in southern Croatia. Materials and Methods An observational retrospective study was conducted over a 1-year period. The subjects were patients admitted to the intensive care unit for acute poisoning. Results In all, 81 subjects (32.1% females) aged 43.16 ± 14.77 years were admitted to the intensive care unit because of poisoning (14.97% of the total annual intensive care unit admissions). Psychiatric disorders were previously established in 76.5% participants, and 69.1% of all acute intoxications were classified as suicidal. Non- suicidal subjects differed from suicidal subjects in age (37.36 ± 9.71 vs. 45.75 ± 15.93 years ; P = 0.009), in pCO2 (6.38 ± 1.78 vs. 5.50 ± 1.26 kPa ; P = 0.020), in length-of-stay in intensive care unit (median 1.00, interquartile range 1.00 vs. median 2.00, interquartile range 2.00 days ; P = 0.022), and in length-of-stay in hospital (median 2.00, interquartile range 2.00 vs. median 10.50, interquartile range 15.25 days ; P < 0.001). Three (3.7%) patients died. Pharmaceutical psychoactive drug intoxications were the most common poisoning cases ; of these, diazepam was the most frequent (16.8%), followed by ethanol (9.0%) and alprazolam (7.8%). Benzodiazepines/hypnotics were the most common group (28.7%), followed by antipsychotics (13.2%). Intoxications with more than 1 poison accounted for the largest number of cases (67.9%). The number of toxins was significantly correlated with length-of-stay in the hospital (rho = −0.265 ; P = 0.008), systolic blood pressure (rho = −0.318 ; P = 0.002), and diastolic blood pressure (rho = −0.262 ; P = 0.009). The electrocardiogram was considered abnormal in 50.62% of the cases. Conclusion Acute intoxicants were most commonly caused by psychiatric pharmaceutical drugs. Multidrug exposure was a typical pattern of acute intoxication.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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