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Pregled bibliografske jedinice broj: 1282604

Control of crystal shape in the batch crystallization process


Prlić Kardum, Jasna; Hrkovac, Martina; Gretić, Matija
Control of crystal shape in the batch crystallization process // BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings / Ila, Mitra ; Louhi-Kultanen, Marjatta (ur.).
Helsinki: Aalto University publication series SCIENCE + TECHNOLOGY, 2022. str. 143-149 (poster, nije recenziran, cjeloviti rad (in extenso), znanstveni)


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Naslov
Control of crystal shape in the batch crystallization process

Autori
Prlić Kardum, Jasna ; Hrkovac, Martina ; Gretić, Matija

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings / Ila, Mitra ; Louhi-Kultanen, Marjatta - Helsinki : Aalto University publication series SCIENCE + TECHNOLOGY, 2022, 143-149

ISBN
978-952-64-9622-1

Skup
BIWIC 2022 27th International Workshop on Industrial Crystallization

Mjesto i datum
Helsinki, Finska, 31.08.2022. - 02.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.

Sažetak
Sphere crystallization has emerged as one of the areas of intensive research in the pharmaceutical industry. This design technique enables simultaneous crystallization and agglomeration in a single step, which can have a positive effect on downstream processes, such as filtration and drying. In the batch crystallization process, the effect of the solvent, anti-solvent, and bridging liquid on the granulometric properties and the structure of the anti-arrhythmic drug, dronedarone hydrochloride was examined. Based on the good solubility of dronedarone hydrochloride in acetonitrile and isopropanol that two solvents were selected for further examination. The metastable zone has been determined and the crystallization of two different systems was performed. In order to achieve spherical crystallization, the water was selected anti-solvent while ethyl acetate, hexane, and heptane were applied as breeding liquids. The agglomerates were characterized by stereoscopic microscopes while XRD was used to determine crystal polymorphic forms. Although the shape and size of the crystals have been affected by the choice of solvent systems, their structure has not changed. As different shapes of crystals were obtained in different solvent systems, a drug release test in the phosphate buffer was performed. Needle-like crystals show a gradual release of the drug over time, while spherical clusters dissolve abruptly in a short period of time.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Jasna Prlić Kardum (autor)

Avatar Url Martina Hrkovac (autor)

Avatar Url Matija Gretić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Prlić Kardum, Jasna; Hrkovac, Martina; Gretić, Matija
Control of crystal shape in the batch crystallization process // BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings / Ila, Mitra ; Louhi-Kultanen, Marjatta (ur.).
Helsinki: Aalto University publication series SCIENCE + TECHNOLOGY, 2022. str. 143-149 (poster, nije recenziran, cjeloviti rad (in extenso), znanstveni)
Prlić Kardum, J., Hrkovac, M. & Gretić, M. (2022) Control of crystal shape in the batch crystallization process. U: Ila, M. & Louhi-Kultanen, M. (ur.)BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings.
@article{article, author = {Prli\'{c} Kardum, Jasna and Hrkovac, Martina and Greti\'{c}, Matija}, year = {2022}, pages = {143-149}, keywords = {batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.}, isbn = {978-952-64-9622-1}, title = {Control of crystal shape in the batch crystallization process}, keyword = {batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.}, publisher = {Aalto University publication series SCIENCE + TECHNOLOGY}, publisherplace = {Helsinki, Finska} }
@article{article, author = {Prli\'{c} Kardum, Jasna and Hrkovac, Martina and Greti\'{c}, Matija}, year = {2022}, pages = {143-149}, keywords = {batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.}, isbn = {978-952-64-9622-1}, title = {Control of crystal shape in the batch crystallization process}, keyword = {batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.}, publisher = {Aalto University publication series SCIENCE + TECHNOLOGY}, publisherplace = {Helsinki, Finska} }




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