Pregled bibliografske jedinice broj: 1282604
Control of crystal shape in the batch crystallization process
Control of crystal shape in the batch crystallization process // BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings / Ila, Mitra ; Louhi-Kultanen, Marjatta (ur.).
Helsinki: Aalto University publication series SCIENCE + TECHNOLOGY, 2022. str. 143-149 (poster, nije recenziran, cjeloviti rad (in extenso), znanstveni)
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Naslov
Control of crystal shape in the batch
crystallization process
Autori
Prlić Kardum, Jasna ; Hrkovac, Martina ; Gretić, Matija
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
BIWIC 2022 27th International Workshop on Industrial Crystallization, Proceedings
/ Ila, Mitra ; Louhi-Kultanen, Marjatta - Helsinki : Aalto University publication series SCIENCE + TECHNOLOGY, 2022, 143-149
ISBN
978-952-64-9622-1
Skup
BIWIC 2022 27th International Workshop on Industrial Crystallization
Mjesto i datum
Helsinki, Finska, 31.08.2022. - 02.09.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
batch crystallization, dissolution, dronedarone hydrochloride, spherical crystallization.
Sažetak
Sphere crystallization has emerged as one of the areas of intensive research in the pharmaceutical industry. This design technique enables simultaneous crystallization and agglomeration in a single step, which can have a positive effect on downstream processes, such as filtration and drying. In the batch crystallization process, the effect of the solvent, anti-solvent, and bridging liquid on the granulometric properties and the structure of the anti-arrhythmic drug, dronedarone hydrochloride was examined. Based on the good solubility of dronedarone hydrochloride in acetonitrile and isopropanol that two solvents were selected for further examination. The metastable zone has been determined and the crystallization of two different systems was performed. In order to achieve spherical crystallization, the water was selected anti-solvent while ethyl acetate, hexane, and heptane were applied as breeding liquids. The agglomerates were characterized by stereoscopic microscopes while XRD was used to determine crystal polymorphic forms. Although the shape and size of the crystals have been affected by the choice of solvent systems, their structure has not changed. As different shapes of crystals were obtained in different solvent systems, a drug release test in the phosphate buffer was performed. Needle-like crystals show a gradual release of the drug over time, while spherical clusters dissolve abruptly in a short period of time.
Izvorni jezik
Engleski
Znanstvena područja
Kemijsko inženjerstvo
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb