Naslov
Exercise training and regression of coronary atheromatous plaques

Autori
Čulić, Viktor

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
European Journal of Preventive Cardiology (2023)

Status rada
Poslan

Ključne riječi
Exercise training ; coronary atheromatous plaques

Sažetak
Vesterbekkmo et al. reported the results of the CENIT trial showing a regression of coronary atheroma volume associated with high-intensity interval training (HIIT) in patients with established stable coronary artery disease (CAD) on concomitant chronic lipid-lowering therapy. The patients were included following a successful percutaneous coronary intervention of all haemodynamic significant stenoses with implantation of drug-eluting stents. The regions of interest were lesions with an atherosclerotic plaque compromising the lumen more than 30% by cross-sectional area. However, the authors acknowledged several important limitations such as the small sample size, diminished intended difference in exercise level between the groups, and uncertain exercise levels in the intervention group. When analysing the atheroma regression in the present study, 1 it would be interesting to see whether there was a synergistic effect between HIIT and high-dose statin therapy which was concomitantly used by 72% of the intervention group. There is also a possibility that the favourable response to HIIT is associated with age. In the clinical practice, this may be relevant because it has been estimated that the risk of myocardial infarction triggered by physical exertion in the general population increases by 3% by each additional year of age.2 This is particularly important because we are still lacking data on the long-term exercise in older patients with CAD.3 In addition, it would be useful to know whether the regression was associated with the initial level of total atheroma volume, for example, whether greater coronary atheromatous plaques reduced more significantly in their dimensions when compared with smaller plaques. Finally, it would be interesting to see whether there was any difference in plaque regression with regard to the CAD extension (i.e. multivessel vs. single-vessel disease) or plaque location (i.e. left main coronary artery vs. other coronary segments, or according to specific coronary artery), all of which may have practical clinical implications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA