Naslov
Cholinesterase inhibitors as drugs for Alzheimer's disease

Autori
Bosak, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts Proceedings of 59th Meeting of the Serbian Chemical Society / Šojić Merkulov, Daniela - Beograd : Serbian Chemical Society, 2023, 27-27

ISBN
978-86-7132-081-8

Skup
59th Meeting of the Serbian Chemical Society

Mjesto i datum
Beograd, Srbija, 01.06.2023. - 02.06.2023

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer`s disease ; acetylcholinesterase ; butyrylcholinesterase ; multi-target-directed ligands ; beta secretase 1

Sažetak
Alzheimer's disease (AD) is a neurodegenerative disease with a complex pathophysiology, which despite the significant progress in the field, remains unclear. During the years, a few hypotheses to explain the disease’s progress were developed. The most widespread is cholinergic hypothesis, which assumes that memory impairments in AD are associated with decreased brain levels of the neurotransmitter acetylcholine leading to decline in memory, problems with communication, memory, orientation and judgment. In line with this hypothesis, the inhibition of enzymes involved in acetylcholine breakdown, acetylcholinesterase and butyrylcholinesterase, represents the mainstream in treatment of neurodegenerative diseases associated with declined levels of acetylcholine. Although the complex and multi-layered pathophysiology of AD led to redirecting the ‘magic bullet’ concept of treatment strategy toward the „multi- target-directed ligands“ concept, cholinesterase inhibition remains the most desirable trait of any potential drug candidate. Compounds based on a quinoline structure and compounds with carbamate functionality represent a very promising structural base for development of MTDL compounds due to their high inhibition potency towards human cholinesterases, and ability to act as metal chelators and inhibitors of beta secretase 1 as an additional beneficial activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA