Naslov
Infant’s health risk considering overall exposure to PBDEs from mother’s milk and household dust

Autori
Dvoršćak, Marija ; Jagić, Karla ; Klinčić, Darija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of toxicology: challenges and opportunities / - , 2023, 317-318

ISBN
978-86-917867-3-1

Skup
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of toxicology: challenges and opportunities

Mjesto i datum
Beograd, Srbija, 10.05.2023. - 12.05.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PBDEs ; breast milk ; house dust ; infant’s exposure ; health risk

Sažetak
Polybrominated diphenyl ethers (PBDEs) are lipophilic organic compounds used as flame retardants in building materials and everyday household products. They accumulate in dust, whose ingestion is one of the most important routes of exposure to PBDEs for humans besides diet. They bioaccumulate in lipid-rich tissues and cause adverse health effects. This is why breast milk is the most common and practical tool used for human biomonitoring, especially of infants to whom in this way PBDEs are directly transferred. An integrated study on levels of 7 specific PBDE congeners in human milk samples (N = 21) from primipara mothers living in Zagreb and its surroundings and matched dust samples from their household was conducted. It was observed that infants’ exposure to PBDEs via house dust ingestion is approximately four times higher compared to mothers. Total estimated daily intake (EDI) values for the ∑7PBDEs detected in breast milk and house dust ranged from 0.9 to 41 ng kg-1 day-1 at both the central and worst case scenario due to the fact that the intake of PBDEs via human milk is far more significant (median 99 %) compared to intake via dust ingestion (median ~1 %). The obtained values of hazard indexes (HI) presenting non-carcinogenic risk were <<1, indicating low risk due to PBDEs uptake. Considering the sensitive period of infants’ development and the intake of various pollutants later in life, it is important that the intake of these compounds at this earliest age does not pose a significant risk.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Javno zdravstvo i zdravstvena zaštita

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