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Pregled bibliografske jedinice broj: 1282155

Could drug availability be improved through shape modification?


Prlić Kardum, Jasna; Zokić, Iva; Sokač, Katarina
Could drug availability be improved through shape modification? // Chemical engineering & technology (2023) (znanstveni, prihvaćen)


CROSBI ID: 1282155 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Could drug availability be improved through shape modification?

Autori
Prlić Kardum, Jasna ; Zokić, Iva ; Sokač, Katarina

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Chemical engineering & technology (2023)

Status rada
Prihvaćen

Ključne riječi
batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration

Sažetak
The possibility of spherical agglomeration was investigated for two active pharmaceutical ingredients from different classes of the Biopharmaceutics Classification System. The effects of different batch crystallization solvent systems on the granulometric properties and structures of dronedarone hydrochloride and ceritinib were investigated. Light and stereomicroscopy were used to determine the size and shape of the agglomerates, while X-ray powder diffraction was used to determine the changes in polymorphic form. Since the change in the solvent system had no effect on the crystal structure but did change the size and shape of the crystals, dissolution experiments were carried out to determine drug release profiles.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Katarina Sokač (autor)

Avatar Url Iva Zokić (autor)

Avatar Url Jasna Prlić Kardum (autor)


Citiraj ovu publikaciju:

Prlić Kardum, Jasna; Zokić, Iva; Sokač, Katarina
Could drug availability be improved through shape modification? // Chemical engineering & technology (2023) (znanstveni, prihvaćen)
Prlić Kardum, J., Zokić, I. & Sokač, K. (2023) Could drug availability be improved through shape modification?. Prihvaćen za objavljivanje u Chemical engineering & technology. [Preprint].
@unknown{unknown, author = {Prli\'{c} Kardum, Jasna and Zoki\'{c}, Iva and Soka\v{c}, Katarina}, year = {2023}, keywords = {batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration}, journal = {Chemical engineering and technology}, title = {Could drug availability be improved through shape modification?}, keyword = {batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration} }
@unknown{unknown, author = {Prli\'{c} Kardum, Jasna and Zoki\'{c}, Iva and Soka\v{c}, Katarina}, year = {2023}, keywords = {batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration}, journal = {Chemical engineering and technology}, title = {Could drug availability be improved through shape modification?}, keyword = {batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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