Pregled bibliografske jedinice broj: 1282155
Could drug availability be improved through shape modification?
Could drug availability be improved through shape modification? // Chemical engineering & technology (2023) (znanstveni, prihvaćen)
CROSBI ID: 1282155 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Could drug availability be improved through shape
modification?
Autori
Prlić Kardum, Jasna ; Zokić, Iva ; Sokač, Katarina
Vrsta, podvrsta
Radovi u časopisima,
znanstveni
Izvornik
Chemical engineering & technology (2023)
Status rada
Prihvaćen
Ključne riječi
batch crystallization, ceritinib, dissolution, dronedarone hydrochloride, spherical agglomeration
Sažetak
The possibility of spherical agglomeration was investigated for two active pharmaceutical ingredients from different classes of the Biopharmaceutics Classification System. The effects of different batch crystallization solvent systems on the granulometric properties and structures of dronedarone hydrochloride and ceritinib were investigated. Light and stereomicroscopy were used to determine the size and shape of the agglomerates, while X-ray powder diffraction was used to determine the changes in polymorphic form. Since the change in the solvent system had no effect on the crystal structure but did change the size and shape of the crystals, dissolution experiments were carried out to determine drug release profiles.
Izvorni jezik
Engleski
Znanstvena područja
Kemijsko inženjerstvo
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus