Naslov
Overview of ferrocene peptidomimetics – conformational analysis, DFT study and solid state

Autori
Kovačević, Monika ; Kodrin, Ivan ; Roca, Sunčica ; Molčanov, Krešimir ; Barišić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solid-State Science & Research- Book of Abstracts / Biliškov, Nikola ; Karadeniz, Bahar ; Pantalon Juraj, Natalija - Zagreb : Institut Ruđer Bošković, 2023, 39-39

ISBN
978-953-7941-48-2

Skup
Solid-State Science & Research

Mjesto i datum
Zagreb, Hrvatska, 28.06.2023. - 30.06.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ferocen, konformacijska analiza, peptidomimetici, vodikova veza
(ferrocene, conformational analysis, peptidomimetics, hydrogen bond)

Sažetak
The biological activity, conformational stability, and therapeutic application of peptides depend on their secondary structure. Therefore, the main goal in the design and preparation of synthetic peptides is to nucleate the formation of secondary structure elements. It has been shown that various ferrocene templates, when incorporated into peptides, induce the formation of hydrogen bonds, which allows the formation of turn- and -sheet- like structures [1, 2]. Here, we provide an overview of hydrogen-bonding patterns in ferrocene peptides based on detailed spectroscopic, DFT and crystallographic analyses.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA