Naslov
Serological Response to SARS-CoV-2 Vaccine in Hemodialyzed Patients and the Association with Later COVID-19 Positivity

Autori
Premužić, Vedran ; Stevanović, Ranko ; Vilibić- Čavlek, Tatjana ; Sirovica, Maja ; Stalman, Sara ; Bogdanić, Maja ; Žilić, Denis ; Nakić, Dario ; Santini Dušević, Danijela ; Vojković, Marina ; Barbić, Jerko ; Durlen, Ivan ; Grdan, Željka ; Pavlović, Draško ; Kudumija, Boris ; Sefer, Siniša ; Griparić, Davor ; Rogić, Dunja ; Bubaš, Marija ; Capak, Krunoslav ; Jelaković, Bojan

Izvornik
Antibodies (2073-4468) 12 (2023), 2; 37-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serological response ; SARS-CoV-2 ; hemodialysis ; vaccination ; COVID-19

Sažetak
Background: The effectiveness of the COVID-19 vaccine may differ in hemodialysis patients. The aim of this prospective multicenter study was to determine the degree of serological response to the SARS-CoV-2 vaccine in the population of dialysis patients and its association with later SARS-CoV-2 infections. Methods: A blood sample was taken for the determination of COVID-19 serological status (IgG antibodies) in 706 dialysis patients 16 weeks after vaccination with the second dose (Pfizer-BioNTech). Results: Only 314 (44.5%) hemodialyzed patients had a satisfactory response to the COVID-19 vaccine. Eighty-two patients (11.6%) had a borderline response, while 310 patients (43.9%) had an unsatisfactory (negative) post-vaccinal antibody titer. A longer dialysis vintage had an increased odds ratio (OR) of 1.01 for the occurrence of COVID-19 positivity after vaccination. In the group of subsequently positive patients, 28 patients (13.6%) died from complications of COVID- 19. We have found differences in mean survival time between patients with and without appropriate responses to vaccination in favor of patients with a satisfactory serological response. Conclusions: The results showed that the dialysis population will not have the same serological response to the vaccine as the general population. The majority of dialysis patients did not develop a severe clinical picture or die at the time of positivity for COVID-19.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA