Naslov
Polyphenols and their ferrocene analogues as biologically active compounds with protective effects on cell death induced by polychlorinated biphenyls

Autori
Miletić, Marina ; Murati, Teuta ; Kovač, Veronika ; Kmetič Ivana

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2023

Ključne riječi
resveratrol ; curcumin ; ferrocene analogues ; cell death ; PCB

Sažetak
Polyphenolic compounds have been shown to possess numerous beneficial properties (mainly anti-inflammatory, antioxidant, anticancer). However, scientific studies indicate that their bioavailability is very low. Therefore, considering that bio-organometallic compounds are attributed to enhance absorption and activity properties compared to the parent polyphenolic compound, the aim of our study was to determine potential protective effects of two selected polyphenols – resveratrol (RSV) and curcumin (CRC), as well as their ferrocene analogues (ferrocene triacyl derivative of resveratrol – RF and ferrocene analogue of curcumin – CF) on cell death (primarily, apoptosis and necrosis) induced by selected polychlorinated biphenyls (PCBs) – PCB 77 ("dioxin-like", planar tetrachlorobiphenyl) and PCB 153 ("non-dioxin-like", non-planar hexachlorobiphenyl). Analysis of cell death by flow cytometry showed that pre-incubation of Chinese hamster ovary (CHO-K1) cells with RSV and CRC had a different effect on cell death depending on PCB congener structure. However, pre-incubation of CHO-K1 cells with CF showed a protective effect after treatment with either PCB 153 or PCB 77. Our findings indicate that it is possible to select biologically active compounds (and dosages) that can attenuate the cytotoxic effects of PCBs and contribute to the development of new ferrocene analogues of polyphenols with improved activity.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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