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Pregled bibliografske jedinice broj: 1281341

The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy


Sacher, Josip; Gavran, Matea; Bolf, Nenad; Ujević Andrijić, Željka
The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy // 28 HSKIKI BOOK OF ABSTRACTS
Rovinj, Hrvatska, 2023. str. 169-169 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1281341 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy

Autori
Sacher, Josip ; Gavran, Matea ; Bolf, Nenad ; Ujević Andrijić, Željka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28 HSKIKI BOOK OF ABSTRACTS / - , 2023, 169-169

Skup
28 HSKIKI

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Crystallization ; Calibration model

Sažetak
Crystallization is an important unit operation used in many branches of industry because it is energy efficient way of separating and purifying compounds.[1] It is one of the most important unit operations in the pharmaceutical industry. The industrial control of crystallization is a difficult task because of the stochastic and often unpredictable behavior of the system. With the development of process analytical technology crystallization control has become possible because it has enabled real-time measurement of critical quality attributes. ATR-FTIR spectroscopy has been used to track the concentration during crystallization [2] but the procedure of developing calibration models is time-consuming. The rapid development of the calibration model is done by slowly heating excess solute in a solvent and collecting temperature and spectra. It is assumed that for each temperature the solubility equilibrium has been reached and spectra correspond to the solubility concentration. In this work, the excess amount of glycine was heated from 5 °C to 55 °C during the span of 4.5 hours. The amount of glycine was 5 % higher than the solubility at 55 °C. The particles were grounded with pestle and mortar to achieve a small size of crystals that dissolve quickly. The spectra were recorded every minute together with the temperature. The PLS calibration model relating spectra to saturation temperature was built. The model was tested on an independent data set obtained by repeating the experiment. The results indicate that the model can predict saturation temperature with relatively good accuracy (RMSEP=0.73).

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Željka Ujević Andrijić (autor)

Avatar Url Nenad Bolf (autor)

Avatar Url Matea Gavran (autor)

Avatar Url Josip Sacher (autor)


Citiraj ovu publikaciju:

Sacher, Josip; Gavran, Matea; Bolf, Nenad; Ujević Andrijić, Željka
The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy // 28 HSKIKI BOOK OF ABSTRACTS
Rovinj, Hrvatska, 2023. str. 169-169 (poster, međunarodna recenzija, sažetak, znanstveni)
Sacher, J., Gavran, M., Bolf, N. & Ujević Andrijić, Ž. (2023) The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy. U: 28 HSKIKI BOOK OF ABSTRACTS.
@article{article, author = {Sacher, Josip and Gavran, Matea and Bolf, Nenad and Ujevi\'{c} Andriji\'{c}, \v{Z}eljka}, year = {2023}, pages = {169-169}, keywords = {Crystallization, Calibration model}, title = {The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy}, keyword = {Crystallization, Calibration model}, publisherplace = {Rovinj, Hrvatska} }
@article{article, author = {Sacher, Josip and Gavran, Matea and Bolf, Nenad and Ujevi\'{c} Andriji\'{c}, \v{Z}eljka}, year = {2023}, pages = {169-169}, keywords = {Crystallization, Calibration model}, title = {The rapid development of calibration models for supersaturation tracking using in-situ ATR-FTIR spectroscopy}, keyword = {Crystallization, Calibration model}, publisherplace = {Rovinj, Hrvatska} }




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