Naslov
Impact of COVID-19 pandemic on metastatic colorectal cancer outcomes

Autori
Pavlovic Mavic, Mirjana ; Jaksic, Petra ; Linaric, Petra ; Vazdar, Ljubica ; Tecic Vuger, Ana ; Separovic, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Annals of Oncology Abstract Book / - , 2023, 43-43

Skup
ESMO 25th World Congress on Gastrointestinal Cancer

Mjesto i datum
Barcelona, Španjolska, 28.06.2023. - 01.07.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
colorectal cancer, outcomes, COVID-19

Sažetak
Background: COVID-19 pandemic substantially affected cancer care by affecting diagnostic and treatment opportunities. Patients were more likely to present in worse general condition, in a state of an emergency and with more advanced stage cancers, thus making them less likely to be suitable for treatment. Methods: We conducted a retrospective analysis of patients with metastatic colorectal cancer who initiated their systemic treatment in period from 01/2016 to 02/ 2020 (pre-pandemic group), and compared them to patients whose treatment was initiated during the pandemic (03/2020 to 12/2020 e pandemic group). We collected the data on the existence of initial metastases, affection of liver and multiple metastases in both groups and calculated the overall (OS) and progression free survival (PFS) using the Kaplan-Meier and a Cox hazard ratio model. Results: We included 341 patients before the COVID-19 pandemic and compared them to 100 patients whose treatment plans were initiated during pandemic. There were no significant differences between the pre- pandemic (n¼341) and pandemic group (n¼100) in the initially metastatic disease (P¼0.318), liver spread (P¼0.855) or multiple metastases (P¼0.466). OS was significantly lower in the pandemic group (12.37.0 vs 19.012.7 months ; log rank P < 0.001). Controlling for the effects of age, gender and previous confounders in the Cox model for the OS yielded significantly higher hazard ratio for the pandemic group of 1.93 [95%CI 1.45-2.58]. Despite somewhat longer PFS in the pre-pandemic group (14.39.9 months vs 11.06.8 months), log-rank test in Kaplan-Meier analysis was insignificant (P¼0.429). Conclusions: Despite a profound effect of the pandemic on the health system, we did not detect a substantial deteriorations. The decline in the OS with retained PFS suggests that the predominant causes for higher hazard ratio resided outside oncologic care.

Izvorni jezik
Engleski

POVEZANOST RADA