Naslov
BPC 157 COUNTERACTS VASCULAR “OCCLUSION-LIKE” SYNDROME, AORTIC WALL DAMAGE, ECG DISTURBANCES, HEMODYNAMIC CHANGES AND TISSUE AND ORGAN DAMAGE INDUCED BY ISCHEMIA-REPERFUSION INJURY AND VARIOUS NOXIOUS SUBSTANCES

Autori
Meštrović, Tomislav ; Pavić, Predrag ; Sikirić, Predrag ; Premužić Meštrović, Ivica ; Hriberski, Klaudija ; Brižić, Ivan ; Škorak, Ivan ; Žižek, Helena ; Figl, Josip ; Halužan, Damir ; Crkvenac Gregorek, Andrea ; Lojo, Nermin ; Fiolić, Zlatko ; Šnajdar, Irena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Chirurgica Croatica / Matošević, Petar ; Kovačević, Miljenko - Zagreb : Circulation, 2022, 53-53

Skup
Godišnji kongres Hrvatskog društva za vaskularnu kirurgiju HLZ-a

Mjesto i datum
Opatija, Hrvatska, 27.10.2022. - 29.10.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
stable gastric pentadecapeptid ; BPC 157 ; occlusion-like syndrome ; cytoprotection ; aortic wall injury

Sažetak
Aim: Different noxious substances are known to induce vascular failure syndrome in rats (intracranial, portal and caval hypertension, aortic hypotension, peripheral and central arterial and venous thrombosis), ECG disturbances and histologic signs of multiorgan lesions. The stable gastric pentadecapeptide BPC 157 has already been demonstrated to act as a cytoprotective and organ-protective agent and to mediate fast recruitment of collateral pathways in different rat models of organ and tissue injury. The joint project of Department of vascular surgery at the University Hospital Center Zagreb and Department of Pharmacology at the Zagreb University School of medicine has recently been started to investigate the role of BPC 157 in mitigation of the ECG disturbances, occlusion-like syndrome and tissue lesions in rats induced by calciumchloride, ciprofloxacin, pancreatic enzymes, sotalol as well as ischemia-reperfusion injury. The aim of this presentation is to report on current progress and results, as well as to delineate practical implications. Methods: After being subjugated to various abovementioned noxious agents or procedures, Albino Wistar rats were treated with BPC 157 (10 µg/kg, 10 ng/kg ig or po). Macroscopic presentation of blood vessels and organs was recorded using USB microcamera, and the specimens of brain, lungs, heart, liver, gastrointestinal tract, kidneys and aortic wall were examined histologically. The blood vessels were evaluated for presence of thrombus. Results: Whatever the cause, a typical hemodynamic and tissue injury pattern has been demonstrated, characterized by ECG disturbances, intracranial hypertension, portal and caval hypertension, and aortal hypotension, accompanied by histological evidence of brain, heart, lung, liver, kidney and gastrointestinal tract lesions and with progressive venous and arterial thrombosis. In addition, when ciprofloxacin, calciumchloride or a mixture of pancreatic enzymes were used, a specific histological signs of aortic wall damage were observed. The administration of BPC 157 mitigated all of the abovementioned deleterious consequences of noxious stimuli. Conclusions: BPC 157 administration lessens the histopathological changes in organs, decelerates the degeneration of aortic wall and progression to aneurysms in rats and mitigates deleterious hemodynamic effects of the various abovementioned noxious agents.

Izvorni jezik
Engleski

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