Naslov
ACTH (in)stability

Autori
Bokulić, Adriana ; Ćelap, Ivana ; Leniček Krleža, Jasna ; Unić, Adriana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
EQALM Symposium

Mjesto i datum
Zagreb, Hrvatska, 18.10.2018. - 19.10.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
ACTH, stability, EQA, CROQALM

Sažetak
For period of 2 years (total of 4 surveys), Croatian Centre for Quality Assessment in Laboratory Medicine (CROQALM) was offering proficiency testing for adrenocorticotropin (ACTH). ACTH was part of Module 8 with various other hormones and tumor markers. For Module 8, CROQALM used commercially available control material Acusera Immunoassay Premium Plus manufactured by Randox. In all 4 surveys, we observed high CV for ACTH ranging from 23% to 47% for all participants (N=13-14) and from 25% to 40% for the largest Roche peer group (N=11-12). ACTH instability in patients’ plasma samples is well known. Depending on manufacturer, it can be unstable in control samples as well. Manufacturer claimed ACTH was stable for 4 hours upon reconstitution when stored at 2˚C to 8˚C and all participants have been given the same instruction. Our aim was to evaluate manufacturer’s claim for ACTH stability in control material used by CROQALM.

Izvorni jezik
Engleski

POVEZANOST RADA