Pregled bibliografske jedinice broj: 1281115
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria // Life, 13 (2023), 6; 1280, 15 doi:10.3390/life13061280 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1281115 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
Autori
Ćesić, Diana ; Lugović Mihić, Liborija ; Ozretić, Petar ; Lojkić, Ivana ; Buljan, Marija ; Šitum, Mirna ; Zovak, Mario ; Vidović, Dinko ; Mijić, August ; Galić, Nada ; Tambić Andrašević, Arjana
Izvornik
Life (2075-1729) 13
(2023), 6;
1280, 15
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
chronic spontaneous urticaria ; gut microbiota ; Lachnospiraceae ; short-chain fatty acids
Sažetak
(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as Lachnospiraceae, in skin inflammatory diseases. (2) Goal: This study aimed to compare the abundance of Lachnospiraceae between CSU patients and healthy controls (HCs). (3) Material and methods: In this case–control study, 16S rRNA sequencing was performed to compare the composition of the gut microbiome between 22 CSU patients and 23 HCs. (4) Results: Beta-diversity revealed significant clustering (p < 0.05) between the CSU patients and HCs. Alpha diversity in the CSU group was significantly decreased according to the Evenness index (p < 0.05). The linear discriminant analysis effect size (LEfSe) identified the significant depletion of the Lachnospiraceae family in CSU patients. (5) Conclusion: Our study revealed the dysbiosis of the gut microbiota in CSU patients, including decreased levels of Lachnospiraceae members, responsible for SCFA production, suggesting that SCFAs may contribute to immune dysfunction in the pathogenesis of CSU.We speculate that the modulation of SCFAs could serve as a prospective additional option in CSU treatment.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
NadSve-Sveučilište u Zagrebu-Lugović-2021 - Povezanost obilježja mikrobioma, psihičkog stresa i upale kože (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Lugović-2020 - Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Lugović-2019 - Obilježja mikrobioma i kvalitete života bolesnika s kroničnom urtikarijom (Lugović Mihić, Liborija, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Tambić-2021 - Ispitivanje mikrobioma kože i povezanost s alergijama u bolesnika s periorificijalnim dermatitisom (Tambić Andrašević, Arjana, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Tambić-2020 - Ispitivanje mikrobioma kože kod bolesnika s periorofacijalnim dermatitisom (Tambić Andrašević, Arjana, NadSve ) ( CroRIS)
NadSve-Sveučilište u Zagrebu-Tambić-2019 - Ispitivanje mikrobioma kože kod bolesnika s periorificijalnim dermatitisom (Tambić Andrašević, Arjana, NadSve ) ( CroRIS)
Ustanove:
Hrvatski veterinarski institut, Zagreb,
Stomatološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice",
Klinika za infektivne bolesti "Dr Fran Mihaljević"
Profili:
Nada Galić
(autor)
August Mijić
(autor)
Mirna Šitum
(autor)
Petar Ozretić
(autor)
Arjana Tambić-Andrašević
(autor)
Dinko Vidović
(autor)
Marija Buljan
(autor)
Liborija Lugović Mihić
(autor)
Ivana Lojkić
(autor)
Mario Zovak
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus