Naslov
Runs of homozygosity as an important concept in population genomics

Autori
Čurik, Ino

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of 12th ISABS Conference on Forensic, Anthropological and Medical Genetics / - , 2022, 316-316

Skup
12th ISABS Conference on Forensic, Anthropological and Medical Genetics

Mjesto i datum
Dubrovnik, Hrvatska, 12.07.2022. - 17.07.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Runs of homozygosity ; Population genetics ; Genomics

Sažetak
Runs of homozygosity (ROH) are contiguous long stretches of homozygous genomic regions used to estimate realised autozygosity from high- throughput marker information. I will explain how ROH can be used to infer a number of important genomic population parameters. For example, ROH are used to estimate recent and distant inbreeding at the individual and population level. In addition, ROH are used to estimate inbreeding depression and to map genomic regions with detrimental effects. Genomic regions with above average occurrence of ROH or extreme ROH islands are used to identify genomic regions that exhibit patterns of positive selection. Finally, I will explain how ROH are used to estimate current and historical effective population size. All applications and examples presented are related to animals and humans.

Izvorni jezik
Engleski

Znanstvena područja
Poljoprivreda (agronomija), Interdisciplinarne biotehničke znanosti

POVEZANOST RADA