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Pregled bibliografske jedinice broj: 1280515

The impact of different exposure time frames on the comet assay descriptors: A case of air pollution


Matković, Katarina; Jurič, Andreja; Jakovljević, Ivana; Davila, Silvije; Milić, Mirta; Kašuba, Vilena; Pehnec, Gordana; Brčić Karačonji, Irena; Gajski, Goran; Gerić, Marko
The impact of different exposure time frames on the comet assay descriptors: A case of air pollution // 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities
Beograd, Srbija, 2023. str. 141-142 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1280515 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The impact of different exposure time frames on the comet assay descriptors: A case of air pollution

Autori
Matković, Katarina ; Jurič, Andreja ; Jakovljević, Ivana ; Davila, Silvije ; Milić, Mirta ; Kašuba, Vilena ; Pehnec, Gordana ; Brčić Karačonji, Irena ; Gajski, Goran ; Gerić, Marko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities / - , 2023, 141-142

Skup
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities

Mjesto i datum
Beograd, Srbija, 10.05.2023. - 12.05.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
air pollution, comet test, human biomonitoring

Sažetak
Air pollution represents a major environmental risk to health, facilitating development of many diseases. The effects of air pollution exposure are difficult to determine because the different chemical species in it are not easily definable or measurable, and they can induce additive, synergistic or antagonistic effects. The comet assay is a method successfully used in monitoring air pollution genotoxicity in exposed populations. Hence, we aimed to investigate possible effects of air pollution on DNA integrity using the alkaline comet assay in human peripheral blood cells. The study was conducted during the colder period of the year 2021 and involved 60 healthy subjects (34 females and 26 males), aged 36.4±9.6 years and BMI<30 kg/ m2 living in Zagreb (Croatia). To evaluate potential impact of air pollution on comet assay descriptors, association was made using different time windows of exposure to air pollution prior to blood sampling (1, 3, and 7 days). All measured outdoor air pollution parameters were in agreement with previously reported values, with PM10 particle fraction (particles with aerodynamic diameter less than 10 μm) and benzo[a]pyrene bound to PM10, that occasionally exceeded regulatory limit levels. There was no clear association between measured outdoor air pollution parameters and comet assay descriptors (tail length, intensity, or moment). Statistical analysis was done using Spearman’s correlation and Linear regression modelling. Future research will include the same study design for populations living in other Croatian cities, where we expect exposure to different set of air pollutants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-1192 - Onečišćenje zraka i biomarkeri učinka u ljudi (HUMNap) (Gajski, Goran, HRZZ - 2020-02) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb


Citiraj ovu publikaciju:

Matković, Katarina; Jurič, Andreja; Jakovljević, Ivana; Davila, Silvije; Milić, Mirta; Kašuba, Vilena; Pehnec, Gordana; Brčić Karačonji, Irena; Gajski, Goran; Gerić, Marko
The impact of different exposure time frames on the comet assay descriptors: A case of air pollution // 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities
Beograd, Srbija, 2023. str. 141-142 (poster, međunarodna recenzija, sažetak, znanstveni)
Matković, K., Jurič, A., Jakovljević, I., Davila, S., Milić, M., Kašuba, V., Pehnec, G., Brčić Karačonji, I., Gajski, G. & Gerić, M. (2023) The impact of different exposure time frames on the comet assay descriptors: A case of air pollution. U: 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities.
@article{article, author = {Matkovi\'{c}, Katarina and Juri\v{c}, Andreja and Jakovljevi\'{c}, Ivana and Davila, Silvije and Mili\'{c}, Mirta and Ka\v{s}uba, Vilena and Pehnec, Gordana and Br\v{c}i\'{c} Kara\v{c}onji, Irena and Gajski, Goran and Geri\'{c}, Marko}, year = {2023}, pages = {141-142}, keywords = {air pollution, comet test, human biomonitoring}, title = {The impact of different exposure time frames on the comet assay descriptors: A case of air pollution}, keyword = {air pollution, comet test, human biomonitoring}, publisherplace = {Beograd, Srbija} }
@article{article, author = {Matkovi\'{c}, Katarina and Juri\v{c}, Andreja and Jakovljevi\'{c}, Ivana and Davila, Silvije and Mili\'{c}, Mirta and Ka\v{s}uba, Vilena and Pehnec, Gordana and Br\v{c}i\'{c} Kara\v{c}onji, Irena and Gajski, Goran and Geri\'{c}, Marko}, year = {2023}, pages = {141-142}, keywords = {air pollution, comet test, human biomonitoring}, title = {The impact of different exposure time frames on the comet assay descriptors: A case of air pollution}, keyword = {air pollution, comet test, human biomonitoring}, publisherplace = {Beograd, Srbija} }




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