Pregled bibliografske jedinice broj: 1280515
The impact of different exposure time frames on the comet assay descriptors: A case of air pollution
The impact of different exposure time frames on the comet assay descriptors: A case of air pollution // 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities
Beograd, Srbija, 2023. str. 141-142 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1280515 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The impact of different exposure time frames on the
comet assay descriptors: A case of air pollution
Autori
Matković, Katarina ; Jurič, Andreja ; Jakovljević, Ivana ; Davila, Silvije ; Milić, Mirta ; Kašuba, Vilena ; Pehnec, Gordana ; Brčić Karačonji, Irena ; Gajski, Goran ; Gerić, Marko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities
/ - , 2023, 141-142
Skup
13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference - Present and Future of Toxicology: Challenges and Opportunities
Mjesto i datum
Beograd, Srbija, 10.05.2023. - 12.05.2023
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
air pollution, comet test, human biomonitoring
Sažetak
Air pollution represents a major environmental risk to health, facilitating development of many diseases. The effects of air pollution exposure are difficult to determine because the different chemical species in it are not easily definable or measurable, and they can induce additive, synergistic or antagonistic effects. The comet assay is a method successfully used in monitoring air pollution genotoxicity in exposed populations. Hence, we aimed to investigate possible effects of air pollution on DNA integrity using the alkaline comet assay in human peripheral blood cells. The study was conducted during the colder period of the year 2021 and involved 60 healthy subjects (34 females and 26 males), aged 36.4±9.6 years and BMI<30 kg/ m2 living in Zagreb (Croatia). To evaluate potential impact of air pollution on comet assay descriptors, association was made using different time windows of exposure to air pollution prior to blood sampling (1, 3, and 7 days). All measured outdoor air pollution parameters were in agreement with previously reported values, with PM10 particle fraction (particles with aerodynamic diameter less than 10 μm) and benzo[a]pyrene bound to PM10, that occasionally exceeded regulatory limit levels. There was no clear association between measured outdoor air pollution parameters and comet assay descriptors (tail length, intensity, or moment). Statistical analysis was done using Spearman’s correlation and Linear regression modelling. Future research will include the same study design for populations living in other Croatian cities, where we expect exposure to different set of air pollutants.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-1192 - Onečišćenje zraka i biomarkeri učinka u ljudi (HUMNap) (Gajski, Goran, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Profili:
Vilena Kašuba (autor)
Goran Gajski (autor)
Katarina Matković (autor)
Mirta Milić (autor)
Marko Gerić (autor)
Ivana Jakovljević (autor)
Silvije Davila (autor)
Irena Brčić Karačonji (autor)
Gordana Pehnec (autor)
Andreja Jurič (autor)