Naslov
Sleep quality, excessive daytime sleepiness and increased risk for OSA in patients with osteogenesis imperfecta

Autori
Đogaš, Z ; Pavlinac Dodig, Ivana ; Lusić Kalcina, Linda ; Antičević, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Balancing life with OI - Topical meeting on the impact of pain in osteogenesis imperfecta (OI) / Lande Wekkre, Lena ; Astrom, Eva - Stockholm, 2023, 39-39

Skup
Balancing life with OI - Topical meeting on the impact of pain in osteogenesis imperfecta (OI)

Mjesto i datum
Stockholm, Švedska, 09.06.2023. - 10.06.2023

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
osteogenesis imperfecta, sleep disorders

Sažetak
Objectives: Osteogenesis imperfecta (OI) is a rare genetic disease characterized by disruption of normal collagen formation leading to skeletal vulnerability and consequent frequent skeletal fractures, ligamentous laxity, and scleral discoloration. However, beside the robust symptoms associated with locomotor system, OI might have detrimental effects on quality of life and sleep quality and promote development of various sleep disorders. One of the most common sleep disorders is obstructive sleep apnea (OSA), characterized by repetitive cessations of breathing during sleep and is associated with excessive daytime sleepiness and an increased risk for a number of cardiovascular and metabolic disorders. Recent research and data suggest a bidirectional causality between sleep apnea and disorders of bone metabolism, and a high frequency of sleep apnea has been reported in this population. Such comorbidities, along with pain and fatigue, might contribute to the low sleep quality of OI patients. Thus, our aim was to assess the sleep quality, daytime sleepiness, and risk for OSA among patients with OI. We hypothesized that patients with OI have poor sleep quality, excessive daytime sleepiness and increased risk for OSA. Methods: A total of 20 patients (11 males, 9 females) with OI participated in this research, diagnosed with type 1 (25%), type 3 (40%), and type 4 (30%) OI, and a missing data regarding the type for 1 respondent. The average age of the patients was 26.4±19.4 years. To assess sleep quality, we used Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) was used to assess daytime sleepiness, and STOP and STOP-Bang questionnaires were used for assessment of the risk for OSA. All questionnaires were distributed to OI patients via social networks in an online format. Results: The risk for OSA, according to STOP questionnaire, was reported in 5 (25%) patients, whereas STOP-Bang revealed a risk for OSA in 8 (40%) of patients. Patients reported an average sleep quality PSQI value of 6.1±2.8, with 55% of patients reporting values of PSQI>5, indicating low sleep quality. Average daytime sleepiness assessment showed rather low values of 3.3±2.8, with just one patient reporting excessive daytime sleepiness. Conclusion: In this group of OI patients, STOP- Bang questionnaire more frequently recognized the risk for OSA than the STOP questionnaire. The frequency of this risk was slightly higher when compared to our previously reported values in the general population of similar age. Furthermore, in this group of OI patients, low sleep quality was reported by majority of respondents, which was not the case with excessive daytime sleepiness. Future research should aim to conduct a similar study on a larger group of patients preferably as case control comparisons addressing the postulated reduced sleep quality and elevated risk for OSA in the patients with OI.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA