Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1279559

Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy

Lumi, Xhevat; Confalonieri, Filippo; Ravnik-Glavač, Metka; Goričar, Katja; Blagus, Tanja; Dolžan, Vita; Petrovski, Goran; Hawlina, Marko; Glavač, Damjan
Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy // Genes, 14 (2023), 4; 804, 12 doi:10.3390/genes14040804 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1279559 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy

Autori
Lumi, Xhevat ; Confalonieri, Filippo ; Ravnik-Glavač, Metka ; Goričar, Katja ; Blagus, Tanja ; Dolžan, Vita ; Petrovski, Goran ; Hawlina, Marko ; Glavač, Damjan

Izvornik
Genes (2073-4425) 14 (2023), 4; 804, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rhegmatogenous retinal detachment ; proliferative vitreoretinopathy ; single nucleotide polymorphism ; SNP ; genotyping ; association study ; oxidative stress

Sažetak
This study investigated the association between certain genetic variations and the risk of developing proliferative vitreoretinopathy (PVR) after surgery. The study was conducted on 192 patients with primary rhegmatogenous retinal detachment (RRD) who underwent 3-port pars plana vitrectomy (PPV). The distribution of single nucleotide polymorphisms (SNPs) located in genes involved in inflammation and oxidative stress associated with PVR pathways were analyzed among patients with and without postoperative PVR grade C1 or higher. A total of 7 defined SNPs of 5 genes were selected for genotyping: rs4880 (SOD2) ; rs1001179 (CAT) ; rs1050450 (GPX1) ; rs1143623, rs16944, rs1071676 (IL1B) ; rs2910164 (MIR146A) using competitive allele-specific polymerase chain reaction. The association of SNPs with PVR risk was evaluated using logistic regression. Furthermore, the possible association of SNPs with postoperative clinical parameters was evaluated using nonparametric tests. The difference between two genotype frequencies between patients with or without PVR grade C1 or higher was found to be statistically significant: SOD2 rs4880 and IL1B rs1071676. Carriers of at least one polymorphic IL1B rs1071676 GG allele appeared to have better postoperative best-corrected visual acuity only in patients without PVR (p = 0.070). Our study suggests that certain genetic variations may play a role in the development of PVR after surgery. These findings may have important implications for identifying patients at higher risk for PVR and developing new treatments.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
KBC Split,
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov www.mdpi.com

Citiraj ovu publikaciju:

Lumi, Xhevat; Confalonieri, Filippo; Ravnik-Glavač, Metka; Goričar, Katja; Blagus, Tanja; Dolžan, Vita; Petrovski, Goran; Hawlina, Marko; Glavač, Damjan
Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy // Genes, 14 (2023), 4; 804, 12 doi:10.3390/genes14040804 (međunarodna recenzija, članak, znanstveni)
Lumi, X., Confalonieri, F., Ravnik-Glavač, M., Goričar, K., Blagus, T., Dolžan, V., Petrovski, G., Hawlina, M. & Glavač, D. (2023) Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy. Genes, 14 (4), 804, 12 doi:10.3390/genes14040804.
@article{article, author = {Lumi, Xhevat and Confalonieri, Filippo and Ravnik-Glava\v{c}, Metka and Gori\v{c}ar, Katja and Blagus, Tanja and Dol\v{z}an, Vita and Petrovski, Goran and Hawlina, Marko and Glava\v{c}, Damjan}, year = {2023}, pages = {12}, DOI = {10.3390/genes14040804}, chapter = {804}, keywords = {rhegmatogenous retinal detachment, proliferative vitreoretinopathy, single nucleotide polymorphism, SNP, genotyping, association study, oxidative stress}, journal = {Genes}, doi = {10.3390/genes14040804}, volume = {14}, number = {4}, issn = {2073-4425}, title = {Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy}, keyword = {rhegmatogenous retinal detachment, proliferative vitreoretinopathy, single nucleotide polymorphism, SNP, genotyping, association study, oxidative stress}, chapternumber = {804} }
@article{article, author = {Lumi, Xhevat and Confalonieri, Filippo and Ravnik-Glava\v{c}, Metka and Gori\v{c}ar, Katja and Blagus, Tanja and Dol\v{z}an, Vita and Petrovski, Goran and Hawlina, Marko and Glava\v{c}, Damjan}, year = {2023}, pages = {12}, DOI = {10.3390/genes14040804}, chapter = {804}, keywords = {rhegmatogenous retinal detachment, proliferative vitreoretinopathy, single nucleotide polymorphism, SNP, genotyping, association study, oxidative stress}, journal = {Genes}, doi = {10.3390/genes14040804}, volume = {14}, number = {4}, issn = {2073-4425}, title = {Inflammation and Oxidative Stress Gene Variability in Retinal Detachment Patients with and without Proliferative Vitreoretinopathy}, keyword = {rhegmatogenous retinal detachment, proliferative vitreoretinopathy, single nucleotide polymorphism, SNP, genotyping, association study, oxidative stress}, chapternumber = {804} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.