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Pregled bibliografske jedinice broj: 1279452

Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure.

Agra, Lydianne L.M.; ...; Petrovski, Goran; ...; Melo, Gustavo Barreto
Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure. // Ophthalmology retina (2023) doi:10.1016/j.oret.2023.06.003 (znanstveni, online first)

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Naslov
Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure.

Autori
Agra, Lydianne L.M. ; ... ; Petrovski, Goran ; ... ; Melo, Gustavo Barreto

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Ophthalmology retina (2023)

Status rada
Online first

Ključne riječi
accuracy ; anti-VEGF ; intraocular pressure ; intravitreal injection ; residual volume ; syringe

Sažetak
PURPOSE: To compare accuracy, precision, and residual volume of commonly used syringes for intravitreal injections (IVI), and to assess the intraocular pressure (IOP) rise by variations in volumes delivered. DESIGN: Experimental lab study. SUBJECTS: No subjects were involved in this study. METHODS: We tested 8 syringe models with 2 different needle setups, with 2 different solutions (distilled water or glycerin) and target volumes (50 and 70 muL). To obtain the delivered and residual volumes, we weighed the syringe-needle setups with scale before liquid withdrawal, with liquid, and after liquid release. We also created an experimental eye model to determine the transient rise in IOP following stepwise 10-muL increases in injection volumes. MAIN OUTCOME MEASURES: Delivered and residual volumes, IOP rise. RESULTS: We tested a total of 600 syringe-needle setups. BD Ultra-Fine (0.34 ± 0.28 muL), Zero Residual (1.53 ± 1.15 muL) and Zero Residual Silicone Oil-free (1.40 ± 1.16 muL) syringes showed the lowest residual volume (p<0.001) in comparison to the others (range: 24.86 ± 1.78 muL for Injekt-F to 51.97 ± 3.37 muL for Omnifix-F). The most accurate setups were (percentage deviation from target volume): Zero Residual Silicone Oil-free (+0.70%), Zero Residual 0.3 mL (+4.49%), BD Ultra-Fine (+7.83%), Injekt-F (9.42%), Norm-Ject (+15.88%), Omnifix-F (+16.96%), BD Plastipak Brazil (+17.96%), and BD Plastipak Spain syringes (+19.41%). There was a statistically significant difference between the Zero Residual Silicone Oil-free syringe and all other syringes (p<0.0001), except for the Zero Residual 0.3 mL syringe (p=0.029). The coefficient of variation was low for all syringes. The modeled IOP rise ranged from 32.3 (SD 1.4) mmHg for 20-muL injection volume to 76.5 (SD 1.0) mmHg for 80-muL injection volume. For the standard 50-muL injection volume, the peak pressure was 50.7 (SD 0.1) mmHg, and the pressure rise duration was 28 (SD 2) minutes. CONCLUSIONS: There were significant differences in accuracy and residual volume between syringes, whereas they showed a high precision. Volume excess results in a considerable increase in IOP rise following injection. These findings may provide a relevant overview to clinicians and to both device and drug manufacturers regarding pharmacoeconomic, safety and efficacy issues.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Agra, Lydianne L.M.; ...; Petrovski, Goran; ...; Melo, Gustavo Barreto
Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure. // Ophthalmology retina (2023) doi:10.1016/j.oret.2023.06.003 (znanstveni, online first)
Agra, L., ..., Petrovski, G., ... & Melo, G. (2023) Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure.. Prihvaćen za objavljivanje u Ophthalmology retina. [Preprint] doi:10.1016/j.oret.2023.06.003.
@unknown{unknown, author = {Agra, Lydianne L.M. and Petrovski, Goran and Melo, Gustavo Barreto}, year = {2023}, DOI = {10.1016/j.oret.2023.06.003}, keywords = {accuracy, anti-VEGF, intraocular pressure, intravitreal injection, residual volume, syringe}, journal = {Ophthalmology retina}, doi = {10.1016/j.oret.2023.06.003}, title = {Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure.}, keyword = {accuracy, anti-VEGF, intraocular pressure, intravitreal injection, residual volume, syringe} }
@unknown{unknown, author = {Agra, Lydianne L.M. and Petrovski, Goran and Melo, Gustavo Barreto}, year = {2023}, DOI = {10.1016/j.oret.2023.06.003}, keywords = {accuracy, anti-VEGF, intraocular pressure, intravitreal injection, residual volume, syringe}, journal = {Ophthalmology retina}, doi = {10.1016/j.oret.2023.06.003}, title = {Accuracy, Precision, and Residual Volume of Commonly Used Syringes for Intravitreal Injections and the Impact on Intraocular Pressure.}, keyword = {accuracy, anti-VEGF, intraocular pressure, intravitreal injection, residual volume, syringe} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE

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