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Pregled bibliografske jedinice broj: 1279204

Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy


Golčić, Marin; Simetić, Luka; Herceg, Davorin; Blažičević, Krešimir; Kenđel Jovanović, Gordana; Dražić, Ivan; Belančić, Andrej; Skočibušić, Nataša; Palčevski, Dora; Rubinić, Igor et al.
Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy // Cancers, 15 (2023), 11; 103390, 17 doi:10.3390/cancers15113052 (međunarodna recenzija, članak, znanstveni)


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Naslov
Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy

Autori
Golčić, Marin ; Simetić, Luka ; Herceg, Davorin ; Blažičević, Krešimir ; Kenđel Jovanović, Gordana ; Dražić, Ivan ; Belančić, Andrej ; Skočibušić, Nataša ; Palčevski, Dora ; Rubinić, Igor ; Vlahović-Palčevski, Vera ; Majnarić, Tea ; Dobrila-Dintinjana, Renata ; Pleština, Stjepko

Izvornik
Cancers (2072-6694) 15 (2023), 11; 103390, 17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dietary habits ; gut microbiome ; immunotherapy ; melanoma ; response time

Sažetak
Immunotherapy has improved the prognosis of metastatic melanoma patients, although most patients do not achieve a complete response. While specific gut microbiome and dietary habits might influence treatment success, there is a lack of concordance between the studies, potentially due to dichotomizing patients only into responders and non-responders. The aim of this study was to elucidate whether metastatic melanoma patients with complete and sustained response to immunotherapy exhibit differences in gut microbiome composition among themselves, and whether those differences were associated with specific dietary habits. Shotgun metagenomic sequencing revealed that patients who exhibited a complete response after more than 9 months of treatment (late responders) exhibited a significantly higher beta-diversity (p = 0.02), with a higher abundance of Coprococcus comes (LDA 3.548, p = 0.010), Bifidobacterium pseudocatenulatum (LDA 3.392, p = 0.024), and lower abundance of Prevotellaceae (p = 0.04) compared to early responders. Furthermore, late responders exhibited a different diet profile, with a significantly lower intake of proteins and sweets and a higher intake of flavones (p < 0.05). The research showed that metastatic melanoma patients with a complete and sustained response to immunotherapy were a heterogeneous group. Patients with a late complete response exhibited microbiome and dietary habits which were previously associated with an improved response to immunotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka,
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Golčić, Marin; Simetić, Luka; Herceg, Davorin; Blažičević, Krešimir; Kenđel Jovanović, Gordana; Dražić, Ivan; Belančić, Andrej; Skočibušić, Nataša; Palčevski, Dora; Rubinić, Igor et al.
Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy // Cancers, 15 (2023), 11; 103390, 17 doi:10.3390/cancers15113052 (međunarodna recenzija, članak, znanstveni)
Golčić, M., Simetić, L., Herceg, D., Blažičević, K., Kenđel Jovanović, G., Dražić, I., Belančić, A., Skočibušić, N., Palčevski, D. & Rubinić, I. (2023) Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy. Cancers, 15 (11), 103390, 17 doi:10.3390/cancers15113052.
@article{article, author = {Gol\v{c}i\'{c}, Marin and Simeti\'{c}, Luka and Herceg, Davorin and Bla\v{z}i\v{c}evi\'{c}, Kre\v{s}imir and Ken\djel Jovanovi\'{c}, Gordana and Dra\v{z}i\'{c}, Ivan and Belan\v{c}i\'{c}, Andrej and Sko\v{c}ibu\v{s}i\'{c}, Nata\v{s}a and Pal\v{c}evski, Dora and Rubini\'{c}, Igor and Vlahovi\'{c}-Pal\v{c}evski, Vera and Majnari\'{c}, Tea and Dobrila-Dintinjana, Renata and Ple\v{s}tina, Stjepko}, year = {2023}, pages = {17}, DOI = {10.3390/cancers15113052}, chapter = {103390}, keywords = {dietary habits, gut microbiome, immunotherapy, melanoma, response time}, journal = {Cancers}, doi = {10.3390/cancers15113052}, volume = {15}, number = {11}, issn = {2072-6694}, title = {Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy}, keyword = {dietary habits, gut microbiome, immunotherapy, melanoma, response time}, chapternumber = {103390} }
@article{article, author = {Gol\v{c}i\'{c}, Marin and Simeti\'{c}, Luka and Herceg, Davorin and Bla\v{z}i\v{c}evi\'{c}, Kre\v{s}imir and Ken\djel Jovanovi\'{c}, Gordana and Dra\v{z}i\'{c}, Ivan and Belan\v{c}i\'{c}, Andrej and Sko\v{c}ibu\v{s}i\'{c}, Nata\v{s}a and Pal\v{c}evski, Dora and Rubini\'{c}, Igor and Vlahovi\'{c}-Pal\v{c}evski, Vera and Majnari\'{c}, Tea and Dobrila-Dintinjana, Renata and Ple\v{s}tina, Stjepko}, year = {2023}, pages = {17}, DOI = {10.3390/cancers15113052}, chapter = {103390}, keywords = {dietary habits, gut microbiome, immunotherapy, melanoma, response time}, journal = {Cancers}, doi = {10.3390/cancers15113052}, volume = {15}, number = {11}, issn = {2072-6694}, title = {Analysis of the Gut Microbiome and Dietary Habits in Metastatic Melanoma Patients with a Complete and Sustained Response to Immunotherapy}, keyword = {dietary habits, gut microbiome, immunotherapy, melanoma, response time}, chapternumber = {103390} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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