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Pregled bibliografske jedinice broj: 1279001

Comparative analysis of transferrin and IgG N- glycosylation in two human populations

(Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany) Trbojević-Akmačić Irena; Vučković, Frano; Pribić, Tea; Vilaj, Marija; Černigoj, Urh; Vidič, Jana; Šimunović, Jelena; Kępka, Agnieszka; Kolčić, Ivana; Klarić, Lucija et al.
Comparative analysis of transferrin and IgG N- glycosylation in two human populations // Communications biology, 6 (2023), 312; 1-13 doi:10.1038/s42003-023-04685-6 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1279001 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparative analysis of transferrin and IgG N- glycosylation in two human populations

Autori
Trbojević-Akmačić Irena ; Vučković, Frano ; Pribić, Tea ; Vilaj, Marija ; Černigoj, Urh ; Vidič, Jana ; Šimunović, Jelena ; Kępka, Agnieszka ; Kolčić, Ivana ; Klarić, Lucija ; Novokmet, Mislav, Rapp, Erdmann ; Štrancar, Aleš ; Polašek, Ozren, Wilson, James F ; Lauc, Gordan.

Kolaboracija
Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany

Izvornik
Communications biology (2399-3642) 6 (2023), 312; 1-13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human plasma transferrin (Tf), N-glycosylation

Sažetak
Human plasma transferrin (Tf) N-glycosylation has been mostly studied as a marker for congenital disorders of glycosylation, alcohol abuse, and hepatocellular carcinoma. However, inter- individual variability of Tf N-glycosylation is not known, mainly due to technical limitations of Tf isolation in large-scale studies. Here, we present a highly specific robust high-throughput approach for Tf purification from human blood plasma and detailed characterization of Tf N- glycosylation on the level of released glycans by ultra-high-performance liquid chromatography based on hydrophilic interactions and fluorescence detection (HILIC-UHPLC-FLD), exoglycosidase sequencing, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). We perform a large- scale comparative study of Tf and immunoglobulin G (IgG) N-glycosylation analysis in two human populations and demonstrate that Tf N- glycosylation is associated with age and sex, along with multiple biochemical and physiological traits. Observed association patterns differ compared to the IgG N-glycome corroborating tissue-specific N-glycosylation and specific N- glycans’ role in their distinct physiological functions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Profili:

Avatar Url Marija Vilaj (autor)

Avatar Url Frano Vučković (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Mislav Novokmet (autor)

Avatar Url Jelena Šimunović (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com www.nature.com

Poveznice na istraživačke podatke:

www.nature.com

Citiraj ovu publikaciju:

(Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany) Trbojević-Akmačić Irena; Vučković, Frano; Pribić, Tea; Vilaj, Marija; Černigoj, Urh; Vidič, Jana; Šimunović, Jelena; Kępka, Agnieszka; Kolčić, Ivana; Klarić, Lucija et al.
Comparative analysis of transferrin and IgG N- glycosylation in two human populations // Communications biology, 6 (2023), 312; 1-13 doi:10.1038/s42003-023-04685-6 (međunarodna recenzija, članak, znanstveni)
(Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany) (Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany glyXera GmbH, Magdeburg, Germany) Trbojević-Akmačić Irena, Vučković, F., Pribić, T., Vilaj, M., Černigoj, U., Vidič, J., Šimunović, J., Kępka, A., Kolčić, I. & Klarić, L. (2023) Comparative analysis of transferrin and IgG N- glycosylation in two human populations. Communications biology, 6 (312), 1-13 doi:10.1038/s42003-023-04685-6.
@article{article, author = {Vu\v{c}kovi\'{c}, Frano and Pribi\'{c}, Tea and Vilaj, Marija and \v{C}ernigoj, Urh and Vidi\v{c}, Jana and \v{S}imunovi\'{c}, Jelena and K\k{e}pka, Agnieszka and Kol\v{c}i\'{c}, Ivana and Klari\'{c}, Lucija and \v{S}trancar, Ale\v{s} and Lauc, Gordan.}, year = {2023}, pages = {1-13}, DOI = {10.1038/s42003-023-04685-6}, keywords = {Human plasma transferrin (Tf), N-glycosylation}, journal = {Communications biology}, doi = {10.1038/s42003-023-04685-6}, volume = {6}, number = {312}, issn = {2399-3642}, title = {Comparative analysis of transferrin and IgG N- glycosylation in two human populations}, keyword = {Human plasma transferrin (Tf), N-glycosylation} }
@article{article, author = {Vu\v{c}kovi\'{c}, Frano and Pribi\'{c}, Tea and Vilaj, Marija and \v{C}ernigoj, Urh and Vidi\v{c}, Jana and \v{S}imunovi\'{c}, Jelena and K\k{e}pka, Agnieszka and Kol\v{c}i\'{c}, Ivana and Klari\'{c}, Lucija and \v{S}trancar, Ale\v{s} and Lauc, Gordan.}, year = {2023}, pages = {1-13}, DOI = {10.1038/s42003-023-04685-6}, keywords = {Human plasma transferrin (Tf), N-glycosylation}, journal = {Communications biology}, doi = {10.1038/s42003-023-04685-6}, volume = {6}, number = {312}, issn = {2399-3642}, title = {Comparative analysis of transferrin and IgG N- glycosylation in two human populations}, keyword = {Human plasma transferrin (Tf), N-glycosylation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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