Naslov
The feasibility of transfusing ABO and RHD identical platelet concentrates

Autori
Liker, Milica ; Tomac, Gordana ; Plenković, Fini ; Lukić, Marija ; Raos, Mirela ; Golubić Čepulić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Vox Sanguinis, International Journal of Blood Transfusion Medicine / - Volume 116, S 1 : John Wiley & Sons, 2021, 182-182

Skup
31st Regional ISBT Congress ISBT in Focus

Mjesto i datum
Online, 02.06.2021. - 08.06.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ABO identični, koncentrati trombocita
(ABO identical, platelet concentrate)

Sažetak
Background: Platelet concentrates (PCs) are a common, essential therapy used for a prevention and management of bleeding in thrombocytopenic patients. A growing demand for PCs, combined with a relatively short shelf life and geographical distance from blood suppliers compromise PCs availability, particularly ABO and RhD identical PCs. Consequently, PCs are often transfused without regard to ABO and RhD compatibility. ABO non-identical PCs may contain anti-A and anti-B antibodies, as well as soluble ABH antigens that can cause an immune complex formation, a various degree of haemolysis, and a lower platelet count increment. On the other hand, RhD+ PCs may contain residual red blood cells that can cause anti-D alloimmunization if they are given to RhD- recipients. Aims: The aim of the study was to retrospectively analyse PCs use over a 5-year period in order to determine the overall percentage rate of ABO and RhD PCs identical and non-identical transfusions. Materials and methods: University Hospital Centre Zagreb is a large academic hospital. Our transfusion service does not stock PCs on the inventory, except for specific platelet transfusions planned in advance for certain procedures. PCs are delivered on demand from our blood supplier, the Croatian Institute of Transfusion Medicine (CITM). Our policy is to provide ABO and RhD identical transfusions whenever blood supplier’s inventory allows. When this is not feasible, we try to postpone the transfusion until ABO and RhD identical PCs are available. Only if the patient’s clinical condition does not allow delaying platelet transfusion, ABO and RhD non-identical PC are given. When ABO minor incompatible PCs in plasma are given, the volume of incompatible plasma is reduced. In CITM, PCs are obtained either from a single donor apheresis or pooled from 4 units of random donor whole blood. Platelets were stored in plasma until the beginning of 2016 when 70-75% of plasma was replaced with platelet additive solution. Platelet production planning is based on the replenishment model, but it is also adjusted by the daily demands for certain blood group PCs. A retrospective analysis of all platelet transfusions in UHC Zagreb from 2014 to 2018 was performed. ABO and RhD group of transfused PCs and recipients, as well as specific requirements regarding ABO and RhD group for allogenic ABO and RhD mismatched hematopoietic stem cell transplanted (HSCT) patients were extracted from a comprehensive database of the transfusion service. Platelet transfusions were categorized as ABO identical if ABO and RhD type of the patient and PC were identical and in case of ABO HSCT, when the ABO and RhD type of the PC was compatible with both the HSCT donor and the recipient. Results: A total of 46, 351 PCs were transfused to 3, 776 patients. Platelet transfusion by PC’ and patients’ ABO and RhD group are shown in Table 1. Table 1. Distribution of platelet transfusion by patient’ and PCs’ ABO and RhD group Conclusions: In our settings, transfusion of ABO and RhD identical PCs was challenging, but feasible, since 98.0% of all transfused PCs were transfused to ABO identical patients and only 2.7% RhD+ PCs were transfused to RhD- patients.

Izvorni jezik
Engleski

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