Naslov
Design and synthesis of mannosylated ferrocene derivatives of desmuramyl peptides
(Design and synthesis of mannosylated ferrocene derivatives of desmuramyl peptides.)

Autori
Ribić, Rosana ; Petrović Peroković, Vesna ; Car, Željka ; Kovačević, Monika ; Barišić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19th Ružička Days TODAY SCIENCE – TOMORROW INDUSTRY / - , 2022, 48-48

Skup
International Conference 19th Ružička days “TODAY SCIENCE – TOMORROW INDUSTRY”

Mjesto i datum
Vukovar, Hrvatska, 21.09.2022. - 23.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
desmuramyl peptide, ferrocene, mannose, immunomodulation

Sažetak
Muramyl dipeptide (MDP, N-acetylmuramyl-L-alanyl- D-isoglutamine) is the smallest peptidoglycan fragment capable to trigger the immune response. MDP acts as a pathogen-associated molecular pattern and activates the NOD2 receptor [1]. The main parameter for the improvement of NOD2 agonistic properties is increased lipophilicity. Mannose receptors presented on immunocompetent cells are pattern-recognition receptors, as well as NOD2, and consequently they can affect the immune reactions [2]. Therefore, we present the design and synthesis of mannosylated desmuramyl peptides containing ferrocene lipophilic substituents attached at D-isoglutamine of dipeptide pharmacophore through ester or amide bond. Alkyl spacers of different lengths are inserted between peptide and ferrocene unit to further increase lipophilicity of the synthesized compounds.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA