Naslov
Association of the IgG N-glycome with the course of kidney function in type 2 diabetes

Autori
Singh, Sunny S. ; Heijmans, Ralph ; Meulen, Claudia K. E. ; Lieverse, Aloysius G. ; Gornik, Olga ; Sijbrands, Eric J. G. ; Lauc, Gordan ; van Hoek, Mandy

Izvornik
BMJ open diabetes research and care (2052-4897) 8 (2020), 1; E001026, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IgG N-glycans ; N-glycosylation ; diabetes type 2 ; kidney function ; nephropathy

Sažetak
Introduction: Inflammatory processes are thought to be involved in kidney function decline in individuals with type 2 diabetes. Glycosylation of immunoglobulin G (IgG) is an important post- translation process affecting the inflammatory potential of IgG. We investigated the prospective relationship between IgG N-glycosylation patterns and kidney function in type 2 diabetes. Research design and methods: In the DiaGene study, an all-lines-of-care case-control study (n=1886) with mean prospective follow-up of 7.0 years, the association between 58 IgG N-glycan profiles and estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) per year and during total follow-up was analyzed. Models were adjusted for clinical variables and multiple comparisons. Results: Eleven traits were significantly associated with eGFR change per year. Bisecting GlcNAc in fucosylated and fucosylated disialylated structures and monosialylation of fucosylated digalactosylated structures were associated with a faster decrease of eGFR. Fucosylation of neutral and monogalactosylated structures was associated with less eGFR decline per year. No significant associations between IgG glycans and ACR were found. Conclusions: In type 2 diabetes, we found IgG N- glycosylation patterns associated with a faster decline of kidney function, reflecting a pro- inflammatory state of IgG. eGFR, but not ACR, was associated with IgG glycans, which suggests these associations may represent renal macroangiopathy rather than microvascular disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA