Pregled bibliografske jedinice broj: 1278204
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier // Bone, 141 (2020), 115602, 6 doi:10.1016/j.bone.2020.115602 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1278204 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Biology of bone morphogenetic protein in bone
repair and regeneration: A role for autologous
blood coagulum as carrier
Autori
Sampath, T. Kuber ; Vukicevic, Slobodan
Izvornik
Bone (8756-3282) 141
(2020);
115602, 6
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
BMP ; BMP carrier ; Bone formation ; Bone repair
Sažetak
BMPs were purified from demineralized bone matrix based on their ability to induce new bone in vivo and they represent a large member of the TGF-β superfamily of proteins. BMPs serve as morphogenic signals for mesenchymal stem cell migration, proliferation and subsequently differentiation into cartilage and bone during embryonic development. A BMP when implanted with a collagenous carrier in a rat subcutaneous site is capable of inducing new bone by mimicking the cellular events of embryonic bone formation. Based on this biological principle, BMP2 and BMP7 containing collagenous matrix as carrier have been developed as bone graft substitutes for spine fusion and long bone fractures. Here, we describe a novel autologous bone graft substitute that contains BMP6 delivered within an autologous blood coagulum as carrier and summarize the biology of osteogenic BMPs in the context of bone repair and regeneration specifically the critical role that carrier plays to support osteogenesis.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
--KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Ježek, Davor; Vukičević, Slobodan) ( CroRIS)
--779340 - Novi lijek za regeneraciju kostiju Osteogrow: terapeutsko rješenje za lumbalne bolove u leđima (OSTEOproSPINE) (Vukičević, Slobodan) ( CroRIS)
EK-FP7-279239 - Novel Bone Morphogenetic Protein-6 Biocompatible Carrier Device for Bone Regeneration (OSTEOGROW) (Vikić-Topić, Smiljka; Đurđević, Dragan, EK - FP7-HEALTH-2011-two-stage) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Slobodan Vukičević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE