Pregled bibliografske jedinice broj: 1278182
Comparison of synthetic ceramic products formulated with autologous blood coagulum containing rhBMP6 for induction of bone formation
Comparison of synthetic ceramic products formulated with autologous blood coagulum containing rhBMP6 for induction of bone formation // International Orthopaedics, 46 (2022), 11; 2693-2704 doi:10.1007/s00264-022-05546-3 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1278182 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Comparison of synthetic ceramic products
formulated with autologous blood coagulum
containing rhBMP6 for induction of bone formation
Autori
Stokovic, Nikola ; Ivanjko, Natalia ; Rumenovic, Viktorija ; Breski, Anita ; Sampath, Kuber T. ; Peric, Mihaela ; Pecina, Marko ; Vukicevic, Slobodan
Izvornik
International Orthopaedics (0341-2695) 46
(2022), 11;
2693-2704
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
BMP ; Bone morphogenetic proteins ; Bone regeneration ; Calcium phosphate ; Hydroxyapatite ; MicroCT ; Tricalcium phosphate
Sažetak
Purpose: Osteogrow, an osteoinductive device containing recombinant human Bone Morphogenetic Protein 6 (rhBMP6) in autologous blood coagulum, is a novel therapeutic solution for bone regeneration. This study aimed to evaluate different commercially available calcium phosphate synthetic ceramic particles as a compression- resistant matrix (CRM) added to Osteogrow implants to enhance their biomechanical properties. Methods: Osteogrow implants with the addition of Vitoss, ChronOs, BAM, and Dongbo ceramics (Osteogrow-C, where C stands for ceramics) were evaluated in the rodent subcutaneous ectopic bone formation assay. Osteogrow-C device was prepared as follows: rhBMP6 was added to blood, and blood was mixed with ceramics and left to coagulate. Osteogrow-C was implanted subcutaneously in the axillary region of Sprague-Dawley rats and the outcome was analyzed 21 days following implantation using microCT, histology, morphometric analyses, and immunohistochemistry. Results: Osteogrow-C implants with all tested ceramic particles induced the formation of the bone-ceramic structure containing cortical bone, the bone between the particles, and bone at the ceramic surfaces. The amount of newly formed bone was significant in all experimental groups ; however, the highest bone volume was measured in Osteogrow-C implants with highly porous Vitoss ceramics. The trabecular number was highest in Osteogrow-C implants with Vitoss and ChronOs ceramics while trabeculae were thicker in implants containing BAM and Dongbo ceramics. The immunological response and inflammation were comparable among ceramic particles evaluated in this study. Conclusion: Osteogrow-C bone regenerative device was effective with a broad range of commercially available synthetic ceramics providing a promising therapeutic solution for the regeneration of long bone fracture nonunion, large segmental defects, and spinal fusion surgeries.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
--KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Ježek, Davor; Vukičević, Slobodan) ( CroRIS)
EK-FP7-279239 - Novel Bone Morphogenetic Protein-6 Biocompatible Carrier Device for Bone Regeneration (OSTEOGROW) (Vikić-Topić, Smiljka; Đurđević, Dragan, EK - FP7-HEALTH-2011-two-stage) ( CroRIS)
--779340 - Novi lijek za regeneraciju kostiju Osteogrow: terapeutsko rješenje za lumbalne bolove u leđima (OSTEOproSPINE) (Vukičević, Slobodan) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Viktorija Rumenović
(autor)
Slobodan Vukičević
(autor)
Marko Pećina
(autor)
Nikola Štoković
(autor)
Mihaela Perić
(autor)
Natalia Ivanjko
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE