Naslov
SIGNIFICANCE OF PLATELET SEROTONIN CONCENTRATION IN ALLERGIC RHINITIS AND ASTHMA

Autori
Ferara, Nikola ; Lampalo, Marina ; Jukić, Irena ; Bingulac-Popović, Jasna ; Kilić, Paula ; Popović- Grle, Sanja ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd Symposium of the International Contact Dermatitis Research Group (ICDRG) in cooperation with Croatian Dermatovenereological Society of the Croatian Medical Association / - , 2023, 61-61

Skup
2nd Symposium of the International Contact Dermatitis Research Group (ICDRG) in cooperation with Croatian Dermatovenereological Society of the Croatian Medical Association

Mjesto i datum
Split, Hrvatska, 31.03.2023. - 02.04.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
allergic rhinitis ; allergic asthma ; serotonin ; platelets ; allergic diseases ;

Sažetak
Introduction and goal: There is undeniable clinical evidence that platelets are activated in allergic diseases, including asthma, allergic rhinitis (AR) and eczema. More so, experimental models have showed that platelets play pivotal role in the tissue recruitment of leukocytes following exposure to allergens. Allergen triggered platelet activation in an IgE-FcεR- dependent pathway induces secretion of inflammatory mediators such as serotonin (5-HT). The goal of our study was to determine whether peripheral platelets of patients with both AR and asthma have lower concentrations of 5-HT than platelets of healthy subjects, due to their proposed activity and involvement in the disease. Materials and methods: Study included 87 patients with both AR and asthma and 92 healthy control subjects, without AR and asthma. Blood sample was obtained from each participant and platelet 5-HT concentrations were determined via spectrofluorimetric method. Results were analyzed by using Mann - Whitney test. Results:Patients with AR and asthma had significantly (P=0.045) lower platelet 5-HT concentration (0.17-2.01 nmoL/mg protein) in comparison with healthy control subjects (0.45-4.93 nmoL/mg protein). Conclusion: These results reinforce the fact that platelets and serotonin have important role in the course of asthma and AR. Lower 5-HT concentrations in the group of patients could be related to more frequent 5-HT secretion from the platelets, as a consequence of their greater activity. Also, these results are in agreement with recent knowledge that lower platelet 5-HT concentrations in patients with AR could be associated with behavioral changes (general and emotional problems, sleep). Targeting platelets could be the next step in management of allergic diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA