Naslov
Stabilization Mechanisms of Antibiotics in Solution: A Case Study of Ceftriaxone

Autori
Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR 2023 Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Hrvatsko kemijsko društvo, 2023, 31-31

Skup
Adriatic NMR Conference

Mjesto i datum
Mali Ston, Hrvatska, 01.06.2023. - 04.06.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Stabilisation, Antibiotic, Cextriaxone, Solution

Sažetak
Antimicrobial resistance poses a significant challenge for the future of healthcare. As bacteria become increasingly resistant to antibiotics, it becomes more difficult to treat infections and prevent the spread of disease. This can lead to longer hospital stays, increased healthcare costs, and higher rates of morbidity and mortality. Therefore, continuous efforts are being made to discover new antibiotics and to increase the stability and efficacy of existing molecules. There is also an approach known as antimicrobial stewardship, with the overall aim of balancing the need for effective treatment of infections with the need to minimize the emergence of antimicrobial resistance. By embracing antimicrobial stewardship principles, we can further drive the need to utilize current molecules and improve their stability in solution. A prime example of this approach in action is the development of a ready-to-use formulation of vancomycin, which has been made available to healthcare providers. Meanwhile, b-lactam antibiotics remain one of the most important classes of antibiotics, and are still widely used in the fight against bacterial infections. In this study, Ceftriaxone was used as the model compound to investigate the stabilization mechanism based on degradation kinetics, using various techniques. The results show that the stabilization mechanism is specific to the molecule, but understanding the possible non- covalent interactions is still of great benefit for its utilization

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA