Naslov
The Impact of Severe COVID-19 on Plasma Antioxidants

Autori
Žarković, Neven ; Jastrząb, Anna ; Jarocka- Karpowicz, Iwona ; Orehovec, Biserka ; Baršić, Bruno ; Tarle, Marko ; Kmet, Marta ; Lukšić, Ivica ; Łuczaj, Wojciech ; Skrzydlewska, Elżbieta

Izvornik
Molecules (1420-3049) 27 (2022), 16; 36014561, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-HNE-protein adducts ; COVID-19 ; GSH system ; SARS-CoV-2 ; Trx system ; antioxidants ; biomarkers ; lipid peroxidation ; plasma.

Sažetak
Several studies suggested the association of COVID-19 with systemic oxidative stress, in particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate the antioxidant signaling in the plasma of eighty- eight patients upon admission to the Clinical Hospital Dubrava in Zagreb, of which twenty-two died within a week, while the other recovered. The differences between the deceased and the survivors were found, especially in the reduction of superoxide dismutases (SOD-1 and SOD-2) activity, which was accompanied by the alteration in glutathione-dependent system and the intensification of the thioredoxin-dependent system. Reduced levels of non-enzymatic antioxidants, especially tocopherol, were also observed, which correlated with enhanced lipid peroxidation (determined by 4-hydroxynonenal (4- HNE) and neuroprostane levels) and oxidative modifications of proteins assessed as 4-HNE- protein adducts and carbonyl groups. These findings confirm the onset of systemic oxidative stress in patients with severe SARS-CoV-2, especially those who died from COVID-19, as manifested by strongly reduced tocopherol level and SOD activity associated with lipid peroxidation. Therefore, we propose that preventive and/or supplementary use of antioxidants, especially of lipophilic nature, could be beneficial for the treatment of COVID-19 patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA