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Pregled bibliografske jedinice broj: 1277109

The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease


Vuić, Barbara; Miloš, Tina; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Tudor, Lucija; Konjevod, Marcela; Švob Štrac, Dubravka
The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease // 7th Faculty of Science's PhD Student Symposium : Book of abstracts / Pavlek, Katarina (ur.).
Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2023. str. 104-104 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1277109 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease

Autori
Vuić, Barbara ; Miloš, Tina ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Tudor, Lucija ; Konjevod, Marcela ; Švob Štrac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Faculty of Science's PhD Student Symposium : Book of abstracts / Pavlek, Katarina - Zagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2023, 104-104

ISBN
978-953-6076-01-7

Skup
7th Faculty of Science's PhD Student Symposium

Mjesto i datum
Zagreb, Hrvatska, 21.04.2023. - 22.04.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer´s disease ; DHEA ; DHEAS ; C57BL/6 ; 3xTg-AD

Sažetak
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60-70% of all dementia cases. It is a progressive and incurable neurodegenerative disorder characterized by the amyloid beta (Aβ) peptide deposition in the amyloid plaques and accumulation of hyperphosphorylated tau protein in the neurofibrillary tangles. It affects neuronal functioning and connectivity, resulting in a progressive loss of brain functions, with the cortex and hippocampus being primarily affected. The current AD therapy is only effective in alleviating the symptoms, whereas ongoing research aims at discovering new disease-modifying treatment strategies. The neurosteroids dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) have been studied for their neuroprotective potential in AD. Although these steroid hormones are abundant in the human blood, they are also produced de novo in neurons and glial cells, where their concentration is 6-8 times higher in comparison to periphery. In our research, we have utilized both genetic and pharmacologically induced mouse model of AD. The triple-transgenic AD (3xTg-AD) mouse is one of the most appropriate animal models of AD, displaying all main histopathological and behavioral features of AD, including age-dependent development of amyloid plaques, neurofibrillary tangles and progressive cognitive decline. The 3xTg-AD mice and C57BL/6 control mice were chronically treated with DHEAS using subcutaneously intrascapulary implanted osmotic pumps. The pharmacologically induced AD model was established by intracerebroventriculary injecting the C57BL/6 mice with Aβ oligomers and chronically administered with DHEA via intraperitoneal injection. Various cognitive and behavioral tests were performed on both models and analyzed using Noldus EthoVision XT software. Upon completion of the treatments and behavioral testing, the mice were euthanized and their brains were harvested for further analysis. Our results suggest that DHEA(S) could potentially serve as a protective agent against cognitive decline and other symptomatic presentations in mouse models of AD. Nevertheless, further validation of these results is necessary and it is imperative to extend our findings to include human blood samples to investigate potential therapeutic strategies of these neurosteroids in the future.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-6100 - Terapijski potencijal neurosteroida i neurotrofina u demenciji (TePoNeDe) (Švob Štrac, Dubravka, HRZZ - 2019-04) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

drive.google.com phdss.pmf.unizg.hr

Citiraj ovu publikaciju:

Vuić, Barbara; Miloš, Tina; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Tudor, Lucija; Konjevod, Marcela; Švob Štrac, Dubravka
The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease // 7th Faculty of Science's PhD Student Symposium : Book of abstracts / Pavlek, Katarina (ur.).
Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2023. str. 104-104 (poster, domaća recenzija, sažetak, znanstveni)
Vuić, B., Miloš, T., Nikolac Perković, M., Nedić Erjavec, G., Tudor, L., Konjevod, M. & Švob Štrac, D. (2023) The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease. U: Pavlek, K. (ur.)7th Faculty of Science's PhD Student Symposium : Book of abstracts.
@article{article, author = {Vui\'{c}, Barbara and Milo\v{s}, Tina and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Tudor, Lucija and Konjevod, Marcela and \v{S}vob \v{S}trac, Dubravka}, editor = {Pavlek, K.}, year = {2023}, pages = {104-104}, keywords = {Alzheimer´s disease, DHEA, DHEAS, C57BL/6, 3xTg-AD}, isbn = {978-953-6076-01-7}, title = {The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease}, keyword = {Alzheimer´s disease, DHEA, DHEAS, C57BL/6, 3xTg-AD}, publisher = {Prirodoslovno-matemati\v{c}ki fakultet Sveu\v{c}ili\v{s}ta u Zagrebu}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Vui\'{c}, Barbara and Milo\v{s}, Tina and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Tudor, Lucija and Konjevod, Marcela and \v{S}vob \v{S}trac, Dubravka}, editor = {Pavlek, K.}, year = {2023}, pages = {104-104}, keywords = {Alzheimer´s disease, DHEA, DHEAS, C57BL/6, 3xTg-AD}, isbn = {978-953-6076-01-7}, title = {The potential protective role of dehydroepiandrosterone and its sulfate in the genetic and pharmacologically induced animal model of Alzheimer’s disease}, keyword = {Alzheimer´s disease, DHEA, DHEAS, C57BL/6, 3xTg-AD}, publisher = {Prirodoslovno-matemati\v{c}ki fakultet Sveu\v{c}ili\v{s}ta u Zagrebu}, publisherplace = {Zagreb, Hrvatska} }




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