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Pregled bibliografske jedinice broj: 1277098

The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia


Vuić, Barbara; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Tudor, Lucija; Miloš, Tina; Pivac, Nela; Konjevod, Marcela; Švob Štrac, Dubravka
The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia // FENS Forum 2022 : E-Book of abstracts
Pariz, Francuska, 2022. str. 4280-4280 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1277098 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia

Autori
Vuić, Barbara ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Tudor, Lucija ; Miloš, Tina ; Pivac, Nela ; Konjevod, Marcela ; Švob Štrac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FENS Forum 2022 : E-Book of abstracts / - , 2022, 4280-4280

Skup
FENS Forum 2022 International Neuroscience Conference

Mjesto i datum
Pariz, Francuska, 09.07.2022. - 13.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vascular dementia ; oxidative stress ; DHEA ; DHEAS ; BDNF

Sažetak
Vascular dementia (VaD), the second most common form of dementia, is generally underrecognized and still poorly understood disease. It develops when the brain´s blood supply is blocked or reduced, causing deprivation of oxygen and nutrients and resulting in damage and death of neurons. The brain is highly susceptible to oxidative stress, due to its richness in fatty acids sensitive to peroxidation, as well as due to high oxygen consumption and free radicals accumulation. Oxidative stress in VaD, characterized by the exacerbated production of reactive oxygen species and insufficient antioxidant defense system, increases neuronal cell abnormalities and triggers apoptosis, leading to cognitive dysfunction and dementia. Neurosteroids dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEA/S) and neurotrophin brain-derived neurotrophic factor (BDNF) have attracted the attention of researchers investigating their involvement in various brain functions such as neural survival, plasticity, cognition and behavior. The aim of this study was to investigate the protective potential of DHEA/S and BDNF in promoting neuronal survival and preventing oxidative stress caused by brain ischemia, a common characteristic of VaD. Oxygen-glucose deprivation (OGD) was performed in primary mouse neurons derived from C57BL/6 mice, and human SH-SY5Y neuroblastoma cells as in vitro model of VaD. The cells were cultured in glucose- and serum-free medium in a modular incubator chamber filled with N2. Before or after OGD, cells were treated with DHEA/S and BDNF and cell viability and oxidative stress parameters were determined. Our results suggested protective effects of DHEA/S and BDNF against oxidative damage induced by the ischemic injury in neuronal cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-6100 - Terapijski potencijal neurosteroida i neurotrofina u demenciji (TePoNeDe) (Švob Štrac, Dubravka, HRZZ - 2019-04) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

www.fens.org

Citiraj ovu publikaciju:

Vuić, Barbara; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Tudor, Lucija; Miloš, Tina; Pivac, Nela; Konjevod, Marcela; Švob Štrac, Dubravka
The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia // FENS Forum 2022 : E-Book of abstracts
Pariz, Francuska, 2022. str. 4280-4280 (poster, međunarodna recenzija, sažetak, znanstveni)
Vuić, B., Nikolac Perković, M., Nedić Erjavec, G., Tudor, L., Miloš, T., Pivac, N., Konjevod, M. & Švob Štrac, D. (2022) The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia. U: FENS Forum 2022 : E-Book of abstracts.
@article{article, author = {Vui\'{c}, Barbara and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Tudor, Lucija and Milo\v{s}, Tina and Pivac, Nela and Konjevod, Marcela and \v{S}vob \v{S}trac, Dubravka}, year = {2022}, pages = {4280-4280}, keywords = {vascular dementia, oxidative stress, DHEA, DHEAS, BDNF}, title = {The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia}, keyword = {vascular dementia, oxidative stress, DHEA, DHEAS, BDNF}, publisherplace = {Pariz, Francuska} }
@article{article, author = {Vui\'{c}, Barbara and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Tudor, Lucija and Milo\v{s}, Tina and Pivac, Nela and Konjevod, Marcela and \v{S}vob \v{S}trac, Dubravka}, year = {2022}, pages = {4280-4280}, keywords = {vascular dementia, oxidative stress, DHEA, DHEAS, BDNF}, title = {The protective actions of DHEA/S and BDNF against oxidative stress in an in vitro model of vascular dementia}, keyword = {vascular dementia, oxidative stress, DHEA, DHEAS, BDNF}, publisherplace = {Pariz, Francuska} }




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