Naslov
Epidemiology and outcomes of early‑onset AKI in COVID‑19‑related ARDS in comparison with non‑COVID‑19‑related ARDS: insights from two prospective global cohort studies

Autori
McNicholas, Bairbre ; Rezoagli, Emanuele ; Simpkin, Andrew ; Khanna, Sankalp ; Suen, Jacky ; Yeung, Pauline ; Brodie, Daniel ; Li Bassi, Gianluigi ; Pham, Tai ; Bellani, Giacomo ; Fraser, John ; Laffey, John

Kolaboracija
CCCC Consortium

Izvornik
Critical Care (1364-8535) 27 (2023), 3; 36604753, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute kidney injury, Cohort study, COVID-19, 28-day mortality, 90-day mortality, Outcome, ARDS

Sažetak
Background Acute kidney injury (AKI) is a frequent and severe complication of both COVID-19-related acute respiratory distress syndrome (ARDS) and non-COVID-19-related ARDS. The COVID-19 Critical Care Consortium (CCCC) has generated a global data set on the demographics, management and outcomes of critically ill COVID-19 patients. The LUNG-SAFE study was an international prospective cohort study of patients with severe respiratory failure, including ARDS, which pre-dated the pandemic. Methods The incidence, demographic profile, management and outcomes of early AKI in patients undergoing invasive mechanical ventilation for COVID-19-related ARDS were described and compared with AKI in a non-COVID-19-related ARDS cohort. Results Of 18, 964 patients in the CCCC data set, 1699 patients with COVID-19-related ARDS required invasive ventilation and had relevant outcome data. Of these, 110 (6.5%) had stage 1, 94 (5.5%) had stage 2, 151 (8.9%) had stage 3 AKI, while 1214 (79.1%) had no AKI within 48 h of initiating invasive mechanical ventilation. Patients developing AKI were older and more likely to have hypertension or chronic cardiac disease. There were geo-economic differences in the incidence of AKI, with lower incidence of stage 3 AKI in European high-income countries and a higher incidence in patients from middle-income countries. Both 28-day and 90-day mortality risk was increased for patients with stage 2 (HR 2.00, p < 0.001) and stage 3 AKI (HR 1.95, p < 0.001). Compared to non-COVID-19 ARDS, the incidence of shock was reduced with lower cardiovascular SOFA score across all patient groups, while hospital mortality was worse in all groups [no AKI (30 vs 50%), Stage 1 (38 vs 58%), Stage 2 (56 vs 74%), and Stage 3 (52 vs 72%), p < 0.001]. The time profile of onset of AKI also differed, with 56% of all AKI occurring in the first 48 h in patients with COVID-19 ARDS compared to 89% in the non- COVID-19 ARDS population. Conclusion AKI is a common and serious complication of COVID-19, with a high mortality rate, which differs by geoeconomic location. Important differences exist in the profile of AKI in COVID-19 versus non- COVID-19 ARDS in terms of their haemodynamic profile, time of onset and clinical outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA