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Pregled bibliografske jedinice broj: 1275637

Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

Amodru, Vincent; Ferriere, Amandine; Tabarin, Antoine; Castinetti, Frederic; Tsagarakis, Stylianos; Toth, Miklos; Feelders, Richard A; Webb, Susan M; Reincke, Martin; Netea-Maier, Romana et al.
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome // European Journal of Endocrinology, 188 (2023), 4; 395-406 doi:10.1093/ejendo/lvad008 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1275637 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

Autori
Amodru, Vincent ; Ferriere, Amandine ; Tabarin, Antoine ; Castinetti, Frederic ; Tsagarakis, Stylianos ; Toth, Miklos ; Feelders, Richard A ; Webb, Susan M ; Reincke, Martin ; Netea-Maier, Romana ; Kastelan, Darko ; Elenkova, Atanaska ; Maiter, Dominique ; Ragnarsson, Oskar ; Santos, Alicia ; Valassi, Elena ; Amaral, C ; Ambrogio, A ; Aranda, G ; Arosio, M ; Balomenaki, M ; Berr-Kirmair, C ; Bertherat, J ; Bolanowski, M ; Bollerslev, J ; Cardoso, H ; Carvalho, D ; Cavagnini, F ; Ceccato, P ; Chabre, O ; Chanson, P ; Christ, E ; Demtröder Zentrum fur Endokrinologie, F ; Denes, J ; Deutschbein, T ; Dimopoulou, C ; Dreval, A ; Droste, M ; Duarte, J S ; Dusek, T ; Ertürk, E ; Evang, J A ; Fajardo, C ; Fazel, J ; Feelders, R A ; Fica, S ; García-Centeno, R ; Ghigo, E ; Goth, M ; Godlewska, M ; Greenman, Y ; Halperin, I ; Hanzu, F A ; Hermus, A ; Johannsson, G ; Hubina, E ; Januszewska, A ; Kamenicky, P ; Kasperlik-Zaluska, A ; Kirchner, J ; Kastelan, D ; Komerdus, I ; Kraljevic, I ; Krsek, M ; Kruszynska, A ; Lamas, C ; Lambrescu, I ; Lang, S ; Luger, A ; Maiter, D ; Marpole, N ; Martin, S ; Martinie, M ; Martins Oliveira, M J ; Moros, O ; Netea-Maier, R ; Newell-Price, J ; Orbetzova, M ; Paiva, I ; Pecori Giraldi, F ; Percovich, J C ; Pereira, A M ; Pfeifer, M ; Pickel, J ; Pirags, V ; Ragnarsson, O ; Reghina, A D ; Reincke, M ; Riesgo, P ; Roberts, M ; Roerink, S ; Roig, O ; Rowan, C ; Rudenko, P ; Salvador, J ; Santos, A ; Scaroni, C ; Sigurjonsdottir, H A ; Skoric Polovina, T ; Smith, R ; Stachowska, B ; Stalla, G ; Strasburger, C ; Tabarin, A ; Terzolo, M ; Tőke, J ; Tóth, M ; Touraine, P ; Trainer, P J ; Tsagarakis, S ; Valassi, E ; Vila, G ; Vinay, S ; Wagenmakers, M ; Werner, S ; Young, J ; Zdunowski, P ; Zopf, K ; Zopp, S ; Zosin, I ; and for the ERCUSYN Study Group

Izvornik
European Journal of Endocrinology (0804-4643) 188 (2023), 4; 395-406

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cushing's syndrome ; aging ; ERCUSYN ; elderly patients

Sažetak
Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 patients with CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent CS (ADR-CS), and 107 (6%) had an ectopic source (ECT-CS). According to the WHO criteria, 1616 patients (90.2%) were classified as younger (<65 years old) and 175 (9.8%) as older (>= 65 years old). Results Older patients were more frequently males and had a lower Body Mass Index (BMI) and waist circumference when compared with the younger. Older patients also had a lower prevalence of skin alterations, depression, hair loss, hirsutism, and reduced libido, but a higher prevalence of muscle weakness, diabetes, hypertension, cardiovascular disease, venous thromboembolism, and bone fractures than younger patients, regardless of sex (P < .01 for all comparisons). Measurement of urinary free cortisol supported the diagnosis of CS less frequently in older patients when compared with the younger (P < .05). An extrasellar macroadenoma (macrocorticotropinoma with extrasellar extension) was more common in older PIT-CS patients than in the younger (P < .01). Older PIT-CS patients more frequently received cortisol-lowering medications and radiotherapy as a first-line treatment, whereas surgery was the preferred approach in the younger (P < .01 for all comparisons). When transsphenoidal surgery was performed, the remission rate was lower in the elderly when compared with their younger counterpart (P < .05). Conclusions Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Amodru, Vincent; Ferriere, Amandine; Tabarin, Antoine; Castinetti, Frederic; Tsagarakis, Stylianos; Toth, Miklos; Feelders, Richard A; Webb, Susan M; Reincke, Martin; Netea-Maier, Romana et al.
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome // European Journal of Endocrinology, 188 (2023), 4; 395-406 doi:10.1093/ejendo/lvad008 (međunarodna recenzija, članak, znanstveni)
Amodru, V., Ferriere, A., Tabarin, A., Castinetti, F., Tsagarakis, S., Toth, M., Feelders, R., Webb, S., Reincke, M. & Netea-Maier, R. (2023) Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome. European Journal of Endocrinology, 188 (4), 395-406 doi:10.1093/ejendo/lvad008.
@article{article, author = {Amodru, Vincent and Ferriere, Amandine and Tabarin, Antoine and Castinetti, Frederic and Tsagarakis, Stylianos and Toth, Miklos and Feelders, Richard A and Webb, Susan M and Reincke, Martin and Netea-Maier, Romana and Kastelan, Darko and Elenkova, Atanaska and Maiter, Dominique and Ragnarsson, Oskar and Santos, Alicia and Valassi, Elena and Amaral, C and Ambrogio, A and Aranda, G and Arosio, M and Balomenaki, M and Berr-Kirmair, C and Bertherat, J and Bolanowski, M and Bollerslev, J and Cardoso, H and Carvalho, D and Cavagnini, F and Ceccato, P and Chabre, O and Chanson, P and Christ, E and Demtr\"{o}der Zentrum fur Endokrinologie, F and Denes, J and Deutschbein, T and Dimopoulou, C and Dreval, A and Droste, M and Duarte, J S and Dusek, T and Ert\"{u}rk, E and Evang, J A and Fajardo, C and Fazel, J and Feelders, R A and Fica, S and Garc\'{\i}a-Centeno, R and Ghigo, E and Goth, M and Godlewska, M and Greenman, Y and Halperin, I and Hanzu, F A and Hermus, A and Johannsson, G and Hubina, E and Januszewska, A and Kamenicky, P and Kasperlik-Zaluska, A and Kirchner, J and Kastelan, D and Komerdus, I and Kraljevic, I and Krsek, M and Kruszynska, A and Lamas, C and Lambrescu, I and Lang, S and Luger, A and Maiter, D and Marpole, N and Martin, S and Martinie, M and Martins Oliveira, M J and Moros, O and Netea-Maier, R and Newell-Price, J and Orbetzova, M and Paiva, I and Pecori Giraldi, F and Percovich, J C and Pereira, A M and Pfeifer, M and Pickel, J and Pirags, V and Ragnarsson, O and Reghina, A D and Reincke, M and Riesgo, P and Roberts, M and Roerink, S and Roig, O and Rowan, C and Rudenko, P and Salvador, J and Santos, A and Scaroni, C and Sigurjonsdottir, H A and Skoric Polovina, T and Smith, R and Stachowska, B and Stalla, G and Strasburger, C and Tabarin, A and Terzolo, M and T\H{o}ke, J and T\'{o}th, M and Touraine, P and Trainer, P J and Tsagarakis, S and Valassi, E and Vila, G and Vinay, S and Wagenmakers, M and Werner, S and Young, J and Zdunowski, P and Zopf, K and Zopp, S and Zosin, I}, year = {2023}, pages = {395-406}, DOI = {10.1093/ejendo/lvad008}, keywords = {Cushing's syndrome, aging, ERCUSYN, elderly patients}, journal = {European Journal of Endocrinology}, doi = {10.1093/ejendo/lvad008}, volume = {188}, number = {4}, issn = {0804-4643}, title = {Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome}, keyword = {Cushing's syndrome, aging, ERCUSYN, elderly patients} }
@article{article, author = {Amodru, Vincent and Ferriere, Amandine and Tabarin, Antoine and Castinetti, Frederic and Tsagarakis, Stylianos and Toth, Miklos and Feelders, Richard A and Webb, Susan M and Reincke, Martin and Netea-Maier, Romana and Kastelan, Darko and Elenkova, Atanaska and Maiter, Dominique and Ragnarsson, Oskar and Santos, Alicia and Valassi, Elena and Amaral, C and Ambrogio, A and Aranda, G and Arosio, M and Balomenaki, M and Berr-Kirmair, C and Bertherat, J and Bolanowski, M and Bollerslev, J and Cardoso, H and Carvalho, D and Cavagnini, F and Ceccato, P and Chabre, O and Chanson, P and Christ, E and Demtr\"{o}der Zentrum fur Endokrinologie, F and Denes, J and Deutschbein, T and Dimopoulou, C and Dreval, A and Droste, M and Duarte, J S and Dusek, T and Ert\"{u}rk, E and Evang, J A and Fajardo, C and Fazel, J and Feelders, R A and Fica, S and Garc\'{\i}a-Centeno, R and Ghigo, E and Goth, M and Godlewska, M and Greenman, Y and Halperin, I and Hanzu, F A and Hermus, A and Johannsson, G and Hubina, E and Januszewska, A and Kamenicky, P and Kasperlik-Zaluska, A and Kirchner, J and Kastelan, D and Komerdus, I and Kraljevic, I and Krsek, M and Kruszynska, A and Lamas, C and Lambrescu, I and Lang, S and Luger, A and Maiter, D and Marpole, N and Martin, S and Martinie, M and Martins Oliveira, M J and Moros, O and Netea-Maier, R and Newell-Price, J and Orbetzova, M and Paiva, I and Pecori Giraldi, F and Percovich, J C and Pereira, A M and Pfeifer, M and Pickel, J and Pirags, V and Ragnarsson, O and Reghina, A D and Reincke, M and Riesgo, P and Roberts, M and Roerink, S and Roig, O and Rowan, C and Rudenko, P and Salvador, J and Santos, A and Scaroni, C and Sigurjonsdottir, H A and Skoric Polovina, T and Smith, R and Stachowska, B and Stalla, G and Strasburger, C and Tabarin, A and Terzolo, M and T\H{o}ke, J and T\'{o}th, M and Touraine, P and Trainer, P J and Tsagarakis, S and Valassi, E and Vila, G and Vinay, S and Wagenmakers, M and Werner, S and Young, J and Zdunowski, P and Zopf, K and Zopp, S and Zosin, I}, year = {2023}, pages = {395-406}, DOI = {10.1093/ejendo/lvad008}, keywords = {Cushing's syndrome, aging, ERCUSYN, elderly patients}, journal = {European Journal of Endocrinology}, doi = {10.1093/ejendo/lvad008}, volume = {188}, number = {4}, issn = {0804-4643}, title = {Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome}, keyword = {Cushing's syndrome, aging, ERCUSYN, elderly patients} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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