Naslov
The Role of GLP1-RAs in Direct Modulation of Lipid Metabolism in Hepatic Tissue as Determined Using In Vitro Models of NAFLD

Autori
Petrovic, Ana ; Igrec, Dunja ; Rozac, Karla ; Bojanic, Kristina ; Kuna, Lucija ; Kolaric, Tea Omanovic ; Mihaljevic, Vjera ; Sikora, Renata ; Smolic, Robert ; Glasnovic, Marija ; Wu, George Y. ; Smolic, Martina

Izvornik
Current Issues in Molecular Biology (1467-3045) 45 (2023), 6; 4544-4556

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GLP-1 ; GLP-1RA ; semaglutide ; liraglutide ; NAFLD ; NASH ; NASF ; in vitro ; cell culture ; lipid metabolism

Sažetak
Glucagon-like peptide 1 receptor agonists (GLP- 1RAs) have been shown to improve glucose and lipid homeostasis, promote weight loss, and reduce cardiovascular risk factors. They are a promising therapeutic option for non-alcoholic fatty liver disease (NAFLD), the most common liver disease, associated with T2DM, obesity, and metabolic syndrome. GLP-1RAs have been approved for the treatment of T2DM and obesity, but not for NAFLD. Most recent clinical trials have suggested the importance of early pharmacologic intervention with GLP-1RAs in alleviating and limiting NAFLD, as well as highlighting the relative scarcity of in vitro studies on semaglutide, indicating the need for further research. However, extra-hepatic factors contribute to the GLP-1RA results of in vivo studies. Cell culture models of NAFLD can be helpful in eliminating extrahepatic effects on the alleviation of hepatic steatosis, modulation of lipid metabolism pathways, reduction of inflammation, and prevention of the progression of NAFLD to severe hepatic conditions. In this review article, we discuss the role of GLP-1 and GLP-1RA in the treatment of NAFLD using human hepatocyte models.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA