Pregled bibliografske jedinice broj: 1274147
Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis
Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis // Frontiers in Psychiatry, 9 (2018), 1, 5 doi:10.3389/fpsyt.2018.00488 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1274147 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effects of Long-Term Multimodal Psychosocial
Treatment on Antipsychotic-Induced Metabolic
Changes in Patients With First Episode Psychosis
Autori
Rojnić Kuzman, Martina ; Bosnjak Kuharic, Dina ; Kekin, Ivana ; Makaric, Porin ; Madzarac, Zoran ; Koricancic Makar, Ana ; Kudlek Mikulic, Suzan ; Bajic, Zarko ; Bistrovic, Petra ; Bonacin, Dora ; Vogrinc, Zeljka
Kolaboracija
HRZZ
Izvornik
Frontiers in Psychiatry (1664-0640) 9
(2018);
1, 5
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
antipsychotics, schizophrenia, first episode psychosis, metabolic abnormalities, weight gain, psychosocial intervention, day hospital
Sažetak
Background: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or short-term effects. This study aims to analyse the effects of a long-term multimodal treatment program for first episode psychosis on antipsychotic-induced metabolic changes. Methods: We enrolled 71 patients with first episode psychosis treated at the Zagreb University Hospital Centre from 2016 until 2018. Participants were assigned to one of the two groups: day hospital program vs. treatment as usual (TAU). Outcomes were: body weight, blood glucose, lipids and cholesterol, psychopathology and global level of functioning during the 18-months follow-up. Results: Although the TAU group gained more weight and had higher increase of blood glucose, while the day hospital group had a higher increase in total cholesterol at 18th month follow-up, after the adjustment for age, gender and baseline measures, the type of treatment was not significantly associated with any of the primary outcome measures. Patients' psychopathology measures significantly decreased and their functional level significantly increased at month 18th in both groups. Conclusion: While both types of treatment were effective in reducing psychopathology and restoring the patients' level of functioning, both were relatively ineffective in counteracting antipsychotic-induced metabolic abnormalities and antipsychotic-induced weight gain.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
--UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (BIS – LF FEP) (Rojnić Kuzman, Martina) ( CroRIS)
Profili:
Martina Rojnić Kuzman
(autor)
Zoran Madžarac
(autor)
Petra Bistrović
(autor)
Željka Vogrinc
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus