Pregled bibliografske jedinice broj: 1274144
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY // Psychiatria Danubina, 31 (2019), 2; 162-171 doi:10.24869/psyd.2019.162 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1274144 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN
PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH
PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY
Autori
Rojnić Kuzman, Martina ; Makaric, Porin ; Bosnjak Kuharic, Dina ; Kekin, Ivana ; Rossini Gajsak, Linda ; Boban, Marina ; Bozina, Nada ; Bozina, Tamara ; Celic Ruzic, Mirela ; Darmopil, Sanja ; Filipcic, Igor ; Ganoci, Lana ; Hladnik, Ana ; Madzarac, Zoran ; Malojcic, Branko ; Mihaljevic Peles, Alma ; J. Mueller, Daniel ; Ostojic, Drazenka ; Petanjek, Zdravko ; Petrovic, Ratimir ; Vogrinc, Zeljka ; Savic, Aleksandar ; Silic, Ante ; Sagud, Marina ; Zivkovic, Maja ; Bajic, Zarko ;
Kolaboracija
HRZZ
Izvornik
Psychiatria Danubina (0353-5053) 31
(2019), 2;
162-171
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Psychiatry, biomarkers, first episode psychosis
Sažetak
In this project, we recruited a sample of 150 patients with first episode of psychosis with schizophrenia features (FEP) and 100 healthy controls. We assessed the differences between these two groups, as well as the changes between the acute phase of illness and subsequent remission among patients over 18-month longitudinal follow-up. The assessments were divided into four work packages (WP): WP1- psychopathological status, neurocognitive functioning and emotional recognition ; WP2- stress response measured by saliva cortisol during a stress paradigm ; cerebral blood perfusion in the resting state (with single photon emission computed tomography (SPECT) and during activation paradigm (with Transcranial Ultrasonography Doppler (TCD) ; WP3-post mortem analysis in histologically prepared human cortical tissue of post mortem samples of subjects with schizophrenia in the region that synaptic alteration was suggested by WP1 and WP2 ; WP4- pharmacogenetic analysis (single gene polymorphisms and genome wide association study (GWAS). We expect that the analysis of these data will identify a set of markers that differentiate healthy controls from patients with FEP, and serve as an additional diagnostic tool in the first episode of psychosis, and prediction tool which can be then used to help tailoring individualized treatment options. In this paper, we describe the project protocol including aims and methods and provide a brief description of planned post mortem studies and pharmacogenetic analysis.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
--UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (BIS – LF FEP) (Rojnić Kuzman, Martina) ( CroRIS)
Profili:
Tamara Božina
(autor)
Marina Šagud
(autor)
Draženka Ostojić
(autor)
Maja Živković
(autor)
Ante Silić
(autor)
Zdravko Petanjek
(autor)
Lana Ganoci
(autor)
Alma Mihaljević-Peleš
(autor)
Sanja Darmopil
(autor)
Nada Božina
(autor)
Željka Vogrinc
(autor)
Ana Hladnik
(autor)
Aleksandar Savić
(autor)
Zoran Madžarac
(autor)
Ratimir Petrović
(autor)
Marina Boban
(autor)
Branko Malojčić
(autor)
Igor Filipčić
(autor)
Martina Rojnić Kuzman
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE