Naslov
Procedure of predicting type 2 diabetes development through analysis of n-glycans attached to the plasma proteins of a healthy person

Autori
Gornik, Olga ; Lauc, Gordan ; VUCKOVIC, Frano ; Gornik, Ivan

Nositelj prava
Genos d.o.o., Zagreb, Hrvatska

Sažetak
The present invention relates to a prediction of type 2 diabetes development through quantitative analysis of N-glycans attached to the plasma proteins of a healthy person, which enables determination of whether the investigated person belongs to a risk group for type 2 diabetes development in the future. Obtained quantitative percentages of all analyzed N-glycans are used as input variables of a model F: F(GP1, GP2, …, GPX ; D, S) where X, D and S are parameters of the model F: X = total number of analyzed N-glycans ; D = age of the investigated person ; S = sex of the investigated person ; male= 1, female= 0 ; Constants of the model F (GP1, GP2, …, GPX ; D, S) are obtained by statistical data processing and modelling from analyzed population. Obtained result F for investigated person is then compared with a threshold T, which is statistically determined, and which defines the threshold of increased risk for type 2 diabetes (T2D) development in the future.

Izvorni jezik
Engleski

POVEZANOST RADA