Pregled bibliografske jedinice broj: 1273257
Estrogen withdrawal associated psychosis (EWAP) as a result of hormone replacement treatment discontinuation in a patient with 46, XY gonadal dysgenesis
Estrogen withdrawal associated psychosis (EWAP) as a result of hormone replacement treatment discontinuation in a patient with 46, XY gonadal dysgenesis // ESE Young Endocrinologists and Scientists (EYES) 2022 / European society of Endocrinology (ur.).
Zagreb: BioScientifica, 2022. str. 32-32 doi:10.1530/endoabs.83.rdp7 (predavanje, podatak o recenziji nije dostupan, sažetak, stručni)
CROSBI ID: 1273257 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Estrogen withdrawal
associated psychosis
(EWAP) as a result of
hormone replacement
treatment
discontinuation in a
patient with
46, XY gonadal
dysgenesis
Autori
D., Gasparini ; S., Blazevic Zelic ; J, Vranekovic ; F., M. Wensveen ; T., Turk Wensveen
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni
Skup
ESE Young Endocrinologists and Scientists (EYES) 2022
Mjesto i datum
Zagreb, Hrvatska, 02.09.2022. - 04.09.2022
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Podatak o recenziji nije dostupan
Ključne riječi
estrogen withdrawal, gonadal dysgenesis, psychosis,
(estrogen withdrawal, gonadal dysgenesis, psychosis)
Sažetak
A 20-year-old Caucasian female presented with isolation, suspiciousness, avoidance of communication and insomnia during the last 2 months. The patient displayed paranoia and a lack of insight in her illness. A slow stream of thought process with increased latency and paranoid delusions in thought content were observed. The Minnesota Multiphasic Personality Inventory- 2 showed a positive Goldberg Index, indicating psychotic functioning, with paranoia and schizophrenia in the patient profile basis. Soon after birth, the patient has been diagnosed with GD and has been under HRT, which she quit taking 2 months prior because of her fear of developing breast cancer. Estradiol was re- introduced into the treatment, which alleviated symptoms. Cytogenetic analysis revealed a male 46, XY karyotype. Next- generation sequencing of 25 genes related to GD revealed a heterozygous variant of uncertain significance (VUS) in the luteinizing hormone choriogonadotropin receptor gene and a hemizygous VUS on chromosome X in the androgen receptor gene. Both variants were not previously reported in major databases of population genetic variation. Conclusions: Our findings identify a potential link between discontinuation of estrogen replacement therapy and acute psychosis in the context of GD and stress the importance of proper maintenance of hormonal balance for both the physical and mental health of these patients.
Izvorni jezik
Engleski
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Thalassoterapia Opatija
Profili:
Tamara Turk Wensveen
(autor)
Dora Gašparini
(autor)
Jadranka Vraneković
(autor)
Felix Martinus Wensveen
(autor)
Sandra Blažević Zelić
(autor)