Pregled bibliografske jedinice broj: 1272864
A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P2
A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P2 // Cells, 12 (2023), 10; 1-21 doi:10.3390/cells12101411 (međunarodna recenzija, pregledni rad, znanstveni)
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Naslov
A Plethora of Functions Condensed into Tiny
Phospholipids: The Story of PI4P and PI(4,5)P2
Autori
Bura, Ana ; Čabrijan, Sara ; Đurić, Iris ; Bruketa, Tea ; Jurak Begonja, Antonija
Izvornik
Cells (2073-4409) 12
(2023), 10;
1-21
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
phosphatidylinositol-4-monophosphate ; phosphatidylinositol-4, 5-bisphosphate ; trafficking ; Golgi apparatus ; plasma membrane ; PI4K ; PI4P5KI
Sažetak
Phosphoinositides (PIs) are small, phosphorylated lipids that serve many functions in the cell. They regulate endo- and exocytosis, vesicular trafficking, actin reorganization, and cell mobility, and they act as signaling molecules. The most abundant PIs in the cell are phosphatidylinositol-4-monophosphate (PI4P) and phosphatidylinositol-4, 5-bisphosphate [PI(4, 5)P2]. PI4P is mostly localized at the Golgi apparatus where it regulates the anterograde trafficking from the Golgi apparatus to the plasma membrane (PM), but it also localizes at the PM. On the other hand, the main localization site of PI(4, 5)P2 is the PM where it regulates the formation of endocytic vesicles. The levels of PIs are regulated by many kinases and phosphatases. Four main kinases phosphorylate the precursor molecule phosphatidylinositol into PI4P, divided into two classes (PI4KIIα, PI4KIIβ, PI4KIIIα, and PI4KIIIβ), and three main kinases phosphorylate PI4P to form PI(4, 5)P2 (PI4P5KIα, PI4P5KIβ, and PI4P5KIγ). In this review, we discuss the localization and function of the kinases that produce PI4P and PI(4, 5)P2, as well as the localization and function of their product molecules with an overview of tools for the detection of these PIs.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
HRZZ-DOK-2018-01 - Projekt razvoja karijera mladih istraživača – izobrazba novih doktora znanosti (Jurak Begonja, Antonija, HRZZ - Projekt razvoja karijera mladih istraživača – izobrazba novih doktora znanosti) ( CroRIS)
NadSve-Sveučilište u Rijeci-uniri-biomed-18-188-1343 - Identifikacija novih interakcijskih partnera Vps34 u megakariopoezi (Jurak Begonja, Antonija, NadSve - UNIRI projekti 2018) ( CroRIS)
Ostalo-ASH-2019 - Nucleolar control of megakaryopoiesis (NucMeg) (Jurak Begonja, Antonija, Ostalo - American Society of Hematology (ASH) Global Research Award) ( CroRIS)
HRZZ-UIP-2014-09-2400 - Uloga fosfoinozitida u nastanku trombocita (MkPI) (Jurak Begonja, Antonija, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE