Immunohistochemical Analysis of Adhesion Molecules E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Inflammatory Lesions of Atopic Dermatitis

Marinović Kulišić, Sandra; Takahashi, Marta; Himelreich Perić, Marta; Mužić Radović, Vedrana; Jurakić Tončić, Ružica

doi:10.3390/life13040933

Pregled bibliografske jedinice broj: 1272369

Immunohistochemical Analysis of Adhesion Molecules E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Inflammatory Lesions of Atopic Dermatitis

Marinović Kulišić, Sandra; Takahashi, Marta; Himelreich Perić, Marta; Mužić Radović, Vedrana; Jurakić Tončić, Ružica

Immunohistochemical Analysis of Adhesion Molecules E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Inflammatory Lesions of Atopic Dermatitis // Life, 13 (2023), 4; 933, 12 doi:10.3390/life13040933 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1272369 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Immunohistochemical Analysis of Adhesion Molecules E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Inflammatory Lesions of Atopic Dermatitis

Autori
Marinović Kulišić, Sandra ; Takahashi, Marta ; Himelreich Perić, Marta ; Mužić Radović, Vedrana ; Jurakić Tončić, Ružica

Izvornik
Life (2075-1729) 13 (2023), 4; 933, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
E-selectin, ICAM1, VCAM1, atopic dermatitis

Sažetak
E-selectin, ICAM-1 (intercellular adhesion molecule-1), and VCAM-1 (vascular cell adhesion molecule-1) play a role in atopic dermatitis (AD). This study aimed to evaluate their expression in skin biopsy specimens of patients diagnosed with AD using an optimized computer program. A descriptive analysis and comparison of digitally measured surface area and cell number were performed. The number of E-selectin-positive cells did not vary between the groups. In patients with AD, decreases of 1.2-fold for ICAM-1- and 1.3-fold for VCAM-1- positive cells were observed. The E- selectin-positive epidermal surface area increased (p < 0.001), while ICAM1 and VCAM1 decreased 2.5- fold and 2-fold, respectively, compared to controls. In the AD-affected skin, the E-selectin- positive endothelial area was 3.5-fold larger (p < 0.001), and the ICAM1-positive area was almost 4- fold larger (p < 0.001). E-selectin and ICAM-1 were expressed in the control dermis moderately and weakly, respectively. A strong E-selectin signal was detected in the AD-affected skin macrophages and a strong ICAM-1 signal in the dermal vessel endothelium. In the endothelial cells of AD-affected skin, no VCAM-1 signal could be found. E-selectin, ICAM-1, and VCAM-1 expression show significant disease-specific changes between AD-affected and control skin. The combination of digital analysis and a pathologist’s evaluation may present a valuable follow-up of AD activity parameters.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Profili:

Vedrana Mužić Radović (autor)