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Pregled bibliografske jedinice broj: 1272324

Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents

di Giacomo, Viviana; Ferrante, Claudio; Ronci, Maurizio; Cataldi, Amelia; Di Valerio, Valentina; Rapino, Monica; Recinella, Lucia; Chiavaroli, Annalisa; Leone, Sheila; Vladimir-Knežević, Sanda et al.
Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents // Food and chemical toxicology, 133 (2019), 110783, 9 doi:10.1016/j.fct.2019.110783 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1272324 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents

Autori
Di Giacomo, Viviana ; Ferrante, Claudio ; Ronci, Maurizio ; Cataldi, Amelia ; Di Valerio, Valentina ; Rapino, Monica ; Recinella, Lucia ; Chiavaroli, Annalisa ; Leone, Sheila ; Vladimir-Knežević, Sanda ; Kindl, Marija ; Brunetti, Luigi ; Menghini, Luigi ; Orlando, Giustino

Izvornik
Food and chemical toxicology (0278-6915) 133 (2019); 110783, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Salix alba ; Tanacetum parthenium ; Cortical spreading depression ; Apoptosis ; Serotonin ; Proteomic analysis

Sažetak
Migraine is one of the most common neurological disorder, which has long been related to brain serotonin (5-HT) depletion and neuro-inflammation. Despite many treatment options are available, the frequent occurrence of unacceptable adverse effects further supports the research toward nutraceuticals and herbal preparations, among which Tanacetum parthenium and Salix alba showed promising anti-inflammatory and neuro-modulatory activities. The impact of extract treatment on astrocyte viability, spontaneous migration and apoptosis was evaluated. Anti-inflammatory/anti-oxidant effects were investigated on isolated rat cortexes exposed to a neurotoxic stimulus. The lactate dehydrogenase (LDH) release, nitrite levels and 5-HT turnover were evaluated, as well. A proteomic analysis was focused on specific neuronal proteins and a fingerprint analysis was carried out on selected phenolic compounds. Both extracts appeared able to exert in vitro anti-oxidant and anti-apoptotic effects. S. alba and T. parthenium extracts reduced LDH release, nitrite levels and 5-HT turnover induced by neurotoxic stimulus. The downregulation of selected proteins suggest a neurotoxicity, which could be ascribed to an elevated content of gallic acid in both S. alba and T. parthenium extracts. Concluding, both extracts exert neuroprotective effects, although the downregulation of key proteins involved in neuron physiology suggest caution in their use as food supplements.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Marija Kindl (autor)

Avatar Url Sanda Vladimir-Knežević (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi doi.org

Citiraj ovu publikaciju:

di Giacomo, Viviana; Ferrante, Claudio; Ronci, Maurizio; Cataldi, Amelia; Di Valerio, Valentina; Rapino, Monica; Recinella, Lucia; Chiavaroli, Annalisa; Leone, Sheila; Vladimir-Knežević, Sanda et al.
Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents // Food and chemical toxicology, 133 (2019), 110783, 9 doi:10.1016/j.fct.2019.110783 (međunarodna recenzija, članak, znanstveni)
Di Giacomo, V., Ferrante, C., Ronci, M., Cataldi, A., Di Valerio, V., Rapino, M., Recinella, L., Chiavaroli, A., Leone, S. & Vladimir-Knežević, S. (2019) Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents. Food and chemical toxicology, 133, 110783, 9 doi:10.1016/j.fct.2019.110783.
@article{article, author = {di Giacomo, Viviana and Ferrante, Claudio and Ronci, Maurizio and Cataldi, Amelia and Di Valerio, Valentina and Rapino, Monica and Recinella, Lucia and Chiavaroli, Annalisa and Leone, Sheila and Vladimir-Kne\v{z}evi\'{c}, Sanda and Kindl, Marija and Brunetti, Luigi and Menghini, Luigi and Orlando, Giustino}, year = {2019}, pages = {9}, DOI = {10.1016/j.fct.2019.110783}, chapter = {110783}, keywords = {Salix alba, Tanacetum parthenium, Cortical spreading depression, Apoptosis, Serotonin, Proteomic analysis}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2019.110783}, volume = {133}, issn = {0278-6915}, title = {Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents}, keyword = {Salix alba, Tanacetum parthenium, Cortical spreading depression, Apoptosis, Serotonin, Proteomic analysis}, chapternumber = {110783} }
@article{article, author = {di Giacomo, Viviana and Ferrante, Claudio and Ronci, Maurizio and Cataldi, Amelia and Di Valerio, Valentina and Rapino, Monica and Recinella, Lucia and Chiavaroli, Annalisa and Leone, Sheila and Vladimir-Kne\v{z}evi\'{c}, Sanda and Kindl, Marija and Brunetti, Luigi and Menghini, Luigi and Orlando, Giustino}, year = {2019}, pages = {9}, DOI = {10.1016/j.fct.2019.110783}, chapter = {110783}, keywords = {Salix alba, Tanacetum parthenium, Cortical spreading depression, Apoptosis, Serotonin, Proteomic analysis}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2019.110783}, volume = {133}, issn = {0278-6915}, title = {Multiple pharmacological and toxicological investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents}, keyword = {Salix alba, Tanacetum parthenium, Cortical spreading depression, Apoptosis, Serotonin, Proteomic analysis}, chapternumber = {110783} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Analytical Abstracts
  • EMBASE (Excerpta Medica)

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