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Pregled bibliografske jedinice broj: 1272164

Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study

Sestan, Mario; Kifer, Nastasia; Sozeri, Betul; Demir, Ferhat; Ulu, Kadir; Silva, Clovis A.; Campos, Reinan T.; Batu, Ezgi Deniz; Koker, Oya; Sapina, Matej et al.
Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study // Seminars in Arthritis and Rheumatism, 61 (2023), N/A, 7 doi:10.1016/j.semarthrit.2023.152209 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1272164 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study

Autori
Sestan, Mario ; Kifer, Nastasia ; Sozeri, Betul ; Demir, Ferhat ; Ulu, Kadir ; Silva, Clovis A. ; Campos, Reinan T. ; Batu, Ezgi Deniz ; Koker, Oya ; Sapina, Matej ; Srsen, Sasa ; Held, Martina ; Gagro, Alenka ; Fonseca, Adriana Rodrigues ; Rodrigues, Marta ; Rigante, Donato ; Filocamo, Giovanni ; Baldo, Francesco ; Heshin-Bekenstein, Merav ; Giani, Teresa ; Kataja, Janne ; Frkovic, Marijan ; Ruperto, Nicolino ; Ozen, Seza ; Jelusic, Marija

Izvornik
Seminars in Arthritis and Rheumatism (0049-0172) 61 (2023); N/A, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IgA vasculitis ; Henoch-Schonlein Purpura ; Severe cutaneous manifestations ; Nephritis ; Glucocorticoids

Sažetak
Objective: IgA vasculitis (IgAV) (formerly Henoch- Schönlein Purpura, HSP) rarely causes severe skin lesions in children. The purpose of the research was to determine whether severe skin manifestations were associated with a more severe disease course. Methods: Severe cutaneous manifestations were defined as presence of hemorrhagic vesicles, bullae, ulcerations and/or necroses. Data were collected retrospectively from 12 international tertiary university medical centers. Results: A total of 64 patients with the most severe skin changes in IgAV/HSP and median (Q1, Q3) age of 8.08 (5.08, 11.92) years at the disease onset were compared with 596 IgAV/HSP patients without these manfiestations and median (Q1, Q3) age of 6.33 (4.50, 8.92) years. The patients with severe cutaneous manifestations were older in comparison to other patients with IgAV/HSP (p<0.001), they developed nephritis more frequently (40.6% vs. 20.6%, p=0.001) with worse outcome of renal disease (p=0.001). This group of patients also had higher frequencies of severe gastrointestinal complications like hematochezia, massive bleeding and/or intussusception (29.3% vs. 14.8%, p<0.001). D-dimer concentrations were significantly higher in these patients (4.60 mg/L vs. 2.72 mg/L, p=0.003) and they had more frequent need for treatment with systemic glucocorticoids (84.4% vs. 37.2%, p<0.001) in comparison with the control group. Further multivariate analysis showed that severe cutaneous changes were associated with higher risk of developing nephritis [OR=3.1 (95%CI 1.04-9.21), p=0.042] and severe gastrointestinal complications [OR=3.65 (95%CI 1.08-12.37), p=0.038]. Conclusion: Patients with IgAV/HSP and severe skin manifestations had a more severe clinical course and more frequently required glucocorticoids compared to classic IgAV/HSP patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
IP-2019-04-8822 - Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom (PURPURAPREDICTORS) (Jelušić, Marija, HRZZ - 2019-04) ( CroRIS)

Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
KBC Split,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
Sveučilište u Zagrebu,
Sveučilište J. J. Strossmayera u Osijeku,
Klinika za dječje bolesti,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Nastasia Kifer (autor)

Avatar Url Marija Jelušić (autor)

Avatar Url Matej Šapina (autor)

Avatar Url Alenka Gagro (autor)

Avatar Url Martina Held (autor)

Avatar Url Marijan Frković (autor)

Avatar Url Mario Šestan (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Sestan, Mario; Kifer, Nastasia; Sozeri, Betul; Demir, Ferhat; Ulu, Kadir; Silva, Clovis A.; Campos, Reinan T.; Batu, Ezgi Deniz; Koker, Oya; Sapina, Matej et al.
Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study // Seminars in Arthritis and Rheumatism, 61 (2023), N/A, 7 doi:10.1016/j.semarthrit.2023.152209 (međunarodna recenzija, članak, znanstveni)
Sestan, M., Kifer, N., Sozeri, B., Demir, F., Ulu, K., Silva, C., Campos, R., Batu, E., Koker, O. & Sapina, M. (2023) Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study. Seminars in Arthritis and Rheumatism, 61, N/A, 7 doi:10.1016/j.semarthrit.2023.152209.
@article{article, author = {Sestan, Mario and Kifer, Nastasia and Sozeri, Betul and Demir, Ferhat and Ulu, Kadir and Silva, Clovis A. and Campos, Reinan T. and Batu, Ezgi Deniz and Koker, Oya and Sapina, Matej and Srsen, Sasa and Held, Martina and Gagro, Alenka and Fonseca, Adriana Rodrigues and Rodrigues, Marta and Rigante, Donato and Filocamo, Giovanni and Baldo, Francesco and Heshin-Bekenstein, Merav and Giani, Teresa and Kataja, Janne and Frkovic, Marijan and Ruperto, Nicolino and Ozen, Seza and Jelusic, Marija}, year = {2023}, pages = {7}, DOI = {10.1016/j.semarthrit.2023.152209}, chapter = {N/A}, keywords = {IgA vasculitis, Henoch-Schonlein Purpura, Severe cutaneous manifestations, Nephritis, Glucocorticoids}, journal = {Seminars in Arthritis and Rheumatism}, doi = {10.1016/j.semarthrit.2023.152209}, volume = {61}, issn = {0049-0172}, title = {Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study}, keyword = {IgA vasculitis, Henoch-Schonlein Purpura, Severe cutaneous manifestations, Nephritis, Glucocorticoids}, chapternumber = {N/A} }
@article{article, author = {Sestan, Mario and Kifer, Nastasia and Sozeri, Betul and Demir, Ferhat and Ulu, Kadir and Silva, Clovis A. and Campos, Reinan T. and Batu, Ezgi Deniz and Koker, Oya and Sapina, Matej and Srsen, Sasa and Held, Martina and Gagro, Alenka and Fonseca, Adriana Rodrigues and Rodrigues, Marta and Rigante, Donato and Filocamo, Giovanni and Baldo, Francesco and Heshin-Bekenstein, Merav and Giani, Teresa and Kataja, Janne and Frkovic, Marijan and Ruperto, Nicolino and Ozen, Seza and Jelusic, Marija}, year = {2023}, pages = {7}, DOI = {10.1016/j.semarthrit.2023.152209}, chapter = {N/A}, keywords = {IgA vasculitis, Henoch-Schonlein Purpura, Severe cutaneous manifestations, Nephritis, Glucocorticoids}, journal = {Seminars in Arthritis and Rheumatism}, doi = {10.1016/j.semarthrit.2023.152209}, volume = {61}, issn = {0049-0172}, title = {Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study}, keyword = {IgA vasculitis, Henoch-Schonlein Purpura, Severe cutaneous manifestations, Nephritis, Glucocorticoids}, chapternumber = {N/A} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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