Naslov
ANTIFUNGAL ACTIVITY OF OLIVE LEAF EXTRACT ON ORAL CANDIDA ISOLATES

Autori
Kinkela Devčić Maja, Simonić-Kocijan Suncana, Pasković Igor, Vučinić Davor, Morelato Luka, Sever Ella

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
26th Congress of the Balkan Stomatological Society (BaSS)

Mjesto i datum
Skopje, Sjeverna Makedonija, 11.05.2023. - 14.05.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antifungal activity, Candida, Candida albicans, Olive leaf extract

Sažetak
Introduction: Candida species (Candida spp.) is a part of the normal flora in the oral cavity. Candida may cause various forms of infections, from superficial to systemic conditions. With the increasing use of antifungal agents and a growing number of resistant strains, many researchers are working to find new potential herbal therapeutics that may be a safer alternative in treatment. Among natural products, Olive leaf extract (OLE) is a promising therapeutic tool for the treatment of oral infections due to its antimicrobial activity against a large number of pathogenic microorganisms. Aim: The aim of this study was to determine the antifungal activity of OLE against clinical isolates of Candida spp. Materials and Methods: Using the disc diffusion method, we tested the sensitivity of 15 clinical oral isolates of Candida spp. (11 C.albicans, 3 C. krusei, and 1 C. tropicalis) to four concentrations of OLE (7.5 µg/µL, 15 µg/µL, 30 µg/ µL and 60 µg/µL). Results: All tested concentrations of OLE showed a statistically significantly higher antifungal effect against Candida spp. compared to the control (DMSO). There was a concentration- dependent effect of OLE on the tested samples. Concentrations of 60 µg/µl and 30 µg/µl had statistically significantly higher antifungal activity compared to concentrations of 15 µg/µl and 7.5 µg/µl and a concentration of 30 µg/µl compared to the lowest tested concentration of 7.5 µg/µl. Conclusion: OLE could be a potential drug in the treatment of oral diseases caused by Candida.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina, Poljoprivreda (agronomija)

POVEZANOST RADA