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Pregled bibliografske jedinice broj: 1271506

Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases


Pehar, Vesna; Kolić, Dora; Zandona, Antonio; Šinko, Goran; Katalinić, Maja; Stepanić, Višnja; Kovarik, Zrinka
Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases // Chemico-Biological Interactions, 379 (2023), 110506, 13 doi:10.1016/j.cbi.2023.110506 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1271506 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases

Autori
Pehar, Vesna ; Kolić, Dora ; Zandona, Antonio ; Šinko, Goran ; Katalinić, Maja ; Stepanić, Višnja ; Kovarik, Zrinka

Izvornik
Chemico-Biological Interactions (0009-2797) 379 (2023); 110506, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acetylcholinesterase ; Butamifos ; Cytotoxicity ; Glyphosate ; Neurotoxicity ; Organophosphate pesticides

Sažetak
Sets of 346 herbicides in use and 163 no longer in use were collected from open access online sources and compared in silico with cholinesterases inhibitors (ChI) and drugs in terms of physicochemical profile and estimated toxic effects on human health. The screening revealed at least one potential adverse consequence for each herbicide class assigned according to their mode of action on weeds. The classes with most toxic warnings were K1, K3/N, F1 and E. The selection of 11 commercial herbicides for in vitro biological tests on human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the enzymes involved in neurotoxicity and detoxification of various xenobiotics, respectively, was based mainly on the structural similarity with inhibitors of cholinesterases. Organophosphate anilofos and oxyacetanilide flufenacet were the most potent inhibitors of AChE (25 μM) and BChE (6.4 μM), respectively. Glyphosate, oxadiazon, tembotrione and terbuthylazine were poor inhibitors with an estimated IC50 above 100 μM, while for glyphosate the IC50 was above 1 mM. Generally, all of the selected herbicides inhibited with a slight preference towards BChE. Cytotoxicity assays showed that anilofos, bensulide, butamifos, piperophos and oxadiazon were cytotoxic for hepatocytes (HepG2) and neuroblastoma cell line (SH-SY5Y). Time-independent cytotoxicity accompanied with induction of reactive oxygen species indicated rapid cell death in few hours. Our results based on in silico and in vitro analyses give insight into the potential toxic outcome of herbicides in use and can be applied in the design of new molecules with a less impact on humans and the environment.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Poljoprivreda (agronomija)



POVEZANOST RADA


Projekti:
IP-2018-01-7683 - Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima (AnalyseBChE) (Kovarik, Zrinka, HRZZ - 2018-01) ( CroRIS)
UIP-2017-05-7260 - MOLEKULARNI MEHANIZMI TOKSIČNOSTI PROTUOTROVA I POTENCIJALNIH LIJEKOVA (CellToxTargets) (Katalinić, Maja, HRZZ - 2017-05) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Pehar, Vesna; Kolić, Dora; Zandona, Antonio; Šinko, Goran; Katalinić, Maja; Stepanić, Višnja; Kovarik, Zrinka
Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases // Chemico-Biological Interactions, 379 (2023), 110506, 13 doi:10.1016/j.cbi.2023.110506 (međunarodna recenzija, članak, znanstveni)
Pehar, V., Kolić, D., Zandona, A., Šinko, G., Katalinić, M., Stepanić, V. & Kovarik, Z. (2023) Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases. Chemico-Biological Interactions, 379, 110506, 13 doi:10.1016/j.cbi.2023.110506.
@article{article, author = {Pehar, Vesna and Koli\'{c}, Dora and Zandona, Antonio and \v{S}inko, Goran and Katalini\'{c}, Maja and Stepani\'{c}, Vi\v{s}nja and Kovarik, Zrinka}, year = {2023}, pages = {13}, DOI = {10.1016/j.cbi.2023.110506}, chapter = {110506}, keywords = {Acetylcholinesterase, Butamifos, Cytotoxicity, Glyphosate, Neurotoxicity, Organophosphate pesticides}, journal = {Chemico-Biological Interactions}, doi = {10.1016/j.cbi.2023.110506}, volume = {379}, issn = {0009-2797}, title = {Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases}, keyword = {Acetylcholinesterase, Butamifos, Cytotoxicity, Glyphosate, Neurotoxicity, Organophosphate pesticides}, chapternumber = {110506} }
@article{article, author = {Pehar, Vesna and Koli\'{c}, Dora and Zandona, Antonio and \v{S}inko, Goran and Katalini\'{c}, Maja and Stepani\'{c}, Vi\v{s}nja and Kovarik, Zrinka}, year = {2023}, pages = {13}, DOI = {10.1016/j.cbi.2023.110506}, chapter = {110506}, keywords = {Acetylcholinesterase, Butamifos, Cytotoxicity, Glyphosate, Neurotoxicity, Organophosphate pesticides}, journal = {Chemico-Biological Interactions}, doi = {10.1016/j.cbi.2023.110506}, volume = {379}, issn = {0009-2797}, title = {Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases}, keyword = {Acetylcholinesterase, Butamifos, Cytotoxicity, Glyphosate, Neurotoxicity, Organophosphate pesticides}, chapternumber = {110506} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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