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Pregled bibliografske jedinice broj: 1271199

Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review


Adamec, Ivan; Brecl Jakob, Gregor; Drulović, Jelena; Sellner, Johann; Bilić, Ervina; Sitaš, Barbara; Bilić, Hrvoje; Tamaš, Olivera; Budimkić, Maja; Veselinović, Nikola et al.
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review // Journal of the Neurological Sciences, 443 (2022), 120463, 8 doi:10.1016/j.jns.2022.120463 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1271199 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review

Autori
Adamec, Ivan ; Brecl Jakob, Gregor ; Drulović, Jelena ; Sellner, Johann ; Bilić, Ervina ; Sitaš, Barbara ; Bilić, Hrvoje ; Tamaš, Olivera ; Budimkić, Maja ; Veselinović, Nikola ; Horvat Ledinek, Alenka ; Jerše, Jana ; Gomezelj, Sarah ; Hauer, Larissa ; Krbot Skorić, Magdalena ; Habek, Mario

Izvornik
Journal of the Neurological Sciences (0022-510X) 443 (2022); 120463, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; Myelopathy ; SARS-CoV-2 ; Transverse myelitis

Sažetak
Introduction: We aimed to provide insights into transverse myelitis (TM) following COVID-19 by analyzing cases treated at tertiary care neurology centers and a systemic review of the literature. Methods: The retrospective observational multi- center study was conducted at the four university neurology departments in Croatia, Slovenia, Serbia, and Austria. We searched for acute myelitis cases that occurred during or after COVID-19. A systemic review of the literature on COVID-19 and transverse myelitis was performed. Results: We identified 76 persons with TM associated with COVID-19, 13 from the multi-center study and 63 from the literature review. Most of the participants (55.6%) had an intermediate latency, 25.4% had short and 19% long latency from COVID-19 symptoms to TM. The clinical presentation consisted of the typical TM signs. More than half of the participants had inflammatory changes in the CSF, with rare patients having intrathecal OCB synthesis and positive serology for anti-MOG or anti-AQP4 antibodies. Persons with autonomic symptoms and CSF pleocytosis were significantly more common to have an intermediate latency of 8 to 21 days from COVID-19 to TM (p = 0.005 and p = 0.003 ; respectively). According to logistic regression analysis, only participants with lesions evident on spinal cord MRI compared to normal spinal cord MRI had reduced risks for poor recovery. >80% of participants were treated with a combination of corticosteroids and intravenous immunoglobulins or plasma exchange with 73% having incomplete recovery. Conclusion: Our study further characterizes clinical, laboratory, and MRI features, as well as treatment of TM associated with COVID-19.

Izvorni jezik
Engleski

Znanstvena područja
Elektrotehnika, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Adamec, Ivan; Brecl Jakob, Gregor; Drulović, Jelena; Sellner, Johann; Bilić, Ervina; Sitaš, Barbara; Bilić, Hrvoje; Tamaš, Olivera; Budimkić, Maja; Veselinović, Nikola et al.
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review // Journal of the Neurological Sciences, 443 (2022), 120463, 8 doi:10.1016/j.jns.2022.120463 (međunarodna recenzija, članak, znanstveni)
Adamec, I., Brecl Jakob, G., Drulović, J., Sellner, J., Bilić, E., Sitaš, B., Bilić, H., Tamaš, O., Budimkić, M. & Veselinović, N. (2022) Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review. Journal of the Neurological Sciences, 443, 120463, 8 doi:10.1016/j.jns.2022.120463.
@article{article, author = {Adamec, Ivan and Brecl Jakob, Gregor and Drulovi\'{c}, Jelena and Sellner, Johann and Bili\'{c}, Ervina and Sita\v{s}, Barbara and Bili\'{c}, Hrvoje and Tama\v{s}, Olivera and Budimki\'{c}, Maja and Veselinovi\'{c}, Nikola and Horvat Ledinek, Alenka and Jer\v{s}e, Jana and Gomezelj, Sarah and Hauer, Larissa and Krbot Skori\'{c}, Magdalena and Habek, Mario}, year = {2022}, pages = {8}, DOI = {10.1016/j.jns.2022.120463}, chapter = {120463}, keywords = {COVID-19, Myelopathy, SARS-CoV-2, Transverse myelitis}, journal = {Journal of the Neurological Sciences}, doi = {10.1016/j.jns.2022.120463}, volume = {443}, issn = {0022-510X}, title = {Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review}, keyword = {COVID-19, Myelopathy, SARS-CoV-2, Transverse myelitis}, chapternumber = {120463} }
@article{article, author = {Adamec, Ivan and Brecl Jakob, Gregor and Drulovi\'{c}, Jelena and Sellner, Johann and Bili\'{c}, Ervina and Sita\v{s}, Barbara and Bili\'{c}, Hrvoje and Tama\v{s}, Olivera and Budimki\'{c}, Maja and Veselinovi\'{c}, Nikola and Horvat Ledinek, Alenka and Jer\v{s}e, Jana and Gomezelj, Sarah and Hauer, Larissa and Krbot Skori\'{c}, Magdalena and Habek, Mario}, year = {2022}, pages = {8}, DOI = {10.1016/j.jns.2022.120463}, chapter = {120463}, keywords = {COVID-19, Myelopathy, SARS-CoV-2, Transverse myelitis}, journal = {Journal of the Neurological Sciences}, doi = {10.1016/j.jns.2022.120463}, volume = {443}, issn = {0022-510X}, title = {Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review}, keyword = {COVID-19, Myelopathy, SARS-CoV-2, Transverse myelitis}, chapternumber = {120463} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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