Pregled bibliografske jedinice broj: 1271199
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review // Journal of the Neurological Sciences, 443 (2022), 120463, 8 doi:10.1016/j.jns.2022.120463 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1271199 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Transverse myelitis following COVID-19: Insights from
a multi-center study and systematic literature review
Autori
Adamec, Ivan ; Brecl Jakob, Gregor ; Drulović, Jelena ; Sellner, Johann ; Bilić, Ervina ; Sitaš, Barbara ; Bilić, Hrvoje ; Tamaš, Olivera ; Budimkić, Maja ; Veselinović, Nikola ; Horvat Ledinek, Alenka ; Jerše, Jana ; Gomezelj, Sarah ; Hauer, Larissa ; Krbot Skorić, Magdalena ; Habek, Mario
Izvornik
Journal of the Neurological Sciences (0022-510X) 443
(2022);
120463, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
COVID-19 ; Myelopathy ; SARS-CoV-2 ; Transverse myelitis
Sažetak
Introduction: We aimed to provide insights into transverse myelitis (TM) following COVID-19 by analyzing cases treated at tertiary care neurology centers and a systemic review of the literature. Methods: The retrospective observational multi- center study was conducted at the four university neurology departments in Croatia, Slovenia, Serbia, and Austria. We searched for acute myelitis cases that occurred during or after COVID-19. A systemic review of the literature on COVID-19 and transverse myelitis was performed. Results: We identified 76 persons with TM associated with COVID-19, 13 from the multi-center study and 63 from the literature review. Most of the participants (55.6%) had an intermediate latency, 25.4% had short and 19% long latency from COVID-19 symptoms to TM. The clinical presentation consisted of the typical TM signs. More than half of the participants had inflammatory changes in the CSF, with rare patients having intrathecal OCB synthesis and positive serology for anti-MOG or anti-AQP4 antibodies. Persons with autonomic symptoms and CSF pleocytosis were significantly more common to have an intermediate latency of 8 to 21 days from COVID-19 to TM (p = 0.005 and p = 0.003 ; respectively). According to logistic regression analysis, only participants with lesions evident on spinal cord MRI compared to normal spinal cord MRI had reduced risks for poor recovery. >80% of participants were treated with a combination of corticosteroids and intravenous immunoglobulins or plasma exchange with 73% having incomplete recovery. Conclusion: Our study further characterizes clinical, laboratory, and MRI features, as well as treatment of TM associated with COVID-19.
Izvorni jezik
Engleski
Znanstvena područja
Elektrotehnika, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Fakultet elektrotehnike i računarstva, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
MAGDALENA KRBOT SKORIĆ (autor)
Mario Habek (autor)
Barbara Sitaš (autor)
Ervina Bilić (autor)
Ivan Adamec (autor)
Hrvoje Bilić (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE