Naslov
Prognostic significance of preoperative computed hematological inflammatory parameters in patients with breast cancer

Autori
Popović, Karmela Ana ; Mayer, Ljiljana ; Milas, Ivan ; Gaće, Mihaela ; Šostarić, Milica ; Šekerija, Mario ; Stručić, Franjo ; Verbanac, Donatella

Izvornik
Libri oncologici : Croatian journal of oncology (0300-8142) 50 (2022), 2-3; 66-80

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast cancer ; neutrophil-to-lymphocyte ratio ; NLR ; platelets-to-lymphocyte ratio ; PLR ; systemic immune-inflammation index ; SII ; non-adjuvant treatment

Sažetak
Breast cancer is the most common malignant disease among women, constituting around a quarter of all cancers in women worldwide. This type of cancer is mainly affected by genetic, environmental, and lifestyle factors such as nutrition and physical activity. A retrospective study including 192 women with breast cancer was performed for six years (from 2015 to 2021). We investigated the relationship between indirect hematological parameters, neutrophil-to-lymphocyte ratio – NLR, platelets- to-lymphocyte ratio – PLR, systemic immune- inflammation index – SII, and the treatment outcome. Additionally, we also followed the overall survival (OS) rate. The obtained results report assessed parameters before and after surgical intervention. Of importance is to emphasize that at a cut-off value of 2.65 (P = 0.001) and 3.30 (P < 0.001), a decline in the NLR value was noticed after surgical removal of the breast cancer. The same decrease was observed for SII after surgery (P < 0.001). The study shows that SII is a more relevant parameter than NLR and PLR. The study outcome recommends the cut-off value of 2.65 as the optimal for NLR in predicting the effectiveness and success of the surgical procedure.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA